Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:G6PC_HUMAN
Description:glucose-6-phosphatase, catalytic subunit [Source:HGNC Symbol;Acc:4056]
Location:chr17 q21.31
Node attribute:PPI(target); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
H176IYLAAhFPHQVPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
G6PC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253801K76RCOSMICRenal Cancer21248752
ENSP00000253801V304ITCGAOvarian Cancer21720365, 18772890
ENSP00000253801P116LSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000253801V304ICOSMICOvarian Cancer21720365
ENSP00000253801W250*COSMICMelanoma21499247
ENSP00000253801Y23*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000253801I102VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
G6PC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
G6PC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAKG2_HUMANG6PC_HUMANotherKEGG
FOXO1_HUMANG6PC_HUMANTF -> target geneKEGG
FOXO1_HUMANG6PC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa00010Glycolysis / Gluconeogenesis
hsa00500Starch and sucrose metabolism
hsa00052Galactose metabolism
hsa04910Insulin signaling pathway
hsa01100Metabolic pathways
hsa04973Carbohydrate digestion and absorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0035264multicellular organism growthIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0051156glucose 6-phosphate metabolic processIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0006094gluconeogenesisIEAbiological_process
GO:0005977glycogen metabolic processTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0006641triglyceride metabolic processIEAbiological_process
GO:0004346glucose-6-phosphatase activityIEAmolecular_function
GO:0005980glycogen catabolic processIEAbiological_process
GO:0030176integral to endoplasmic reticulum membraneTAScellular_component
GO:0015760glucose-6-phosphate transportIEAbiological_process
GO:0042593glucose homeostasisIMPbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0004346glucose-6-phosphatase activityIDAmolecular_function
GO:0008202steroid metabolic processIEAbiological_process
GO:0005977glycogen metabolic processIEAbiological_process
GO:0008645hexose transportTASbiological_process
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0042301phosphate ion bindingIMPmolecular_function
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0015758glucose transportTASbiological_process
GO:0046415urate metabolic processIEAbiological_process
GO:0016021integral to membraneIDAcellular_component


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