Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PCKGC_HUMAN
Description:phosphoenolpyruvate carboxykinase 1 (soluble) [Source:HGNC Symbol;Acc:8724]
Location:chr20 q13.31
Node attribute:PPI(target); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y557LTPIGyIPKEDHPRD
T178MTRMGtPVLEAPEPCKPhosphoSitePlus
Y595EDIEKyLEDQVHPRD
Y557LTPIGyIPKEDPEPCKPhosphoSitePlus
Y235SFGSGyGGNSLPEPCKPhosphoSitePlus
S233IISFGsGYGGNPEPCKPhosphoSitePlus

Dephosphorylation site
PCKGC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000319814A464VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000319814A325VCOSMICMelanoma21499247
ENSP00000319814G529CCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000319814Renal CancerNormal vs. CancertissueDown12923786
ENSP00000319814Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
PCKGC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAKG2_HUMANPCKGC_HUMANotherKEGG
FOXO1_HUMANPCKGC_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa04964Proximal tubule bicarbonate reclamation
hsa00010Glycolysis / Gluconeogenesis
hsa00020Citrate cycle (TCA cycle)
hsa03320PPAR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0006107oxaloacetate metabolic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0030145manganese ion bindingIDAmolecular_function
GO:0019003GDP bindingIEAmolecular_function
GO:0006475internal protein amino acid acetylationIDAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0017144drug metabolic processTASbiological_process
GO:0030145manganese ion bindingIEAmolecular_function
GO:0005737cytoplasmISScellular_component
GO:0017076purine nucleotide bindingIEAmolecular_function
GO:0042593glucose homeostasisISSbiological_process
GO:0004611phosphoenolpyruvate carboxykinase activityIEAmolecular_function
GO:0032868response to insulin stimulusIDAbiological_process
GO:0046327glycerol biosynthetic process from pyruvateISSbiological_process
GO:0014823response to activityIEAbiological_process
GO:0006094gluconeogenesisISSbiological_process
GO:0006006glucose metabolic processIMPbiological_process
GO:0031406carboxylic acid bindingIDAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0006006glucose metabolic processIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0005525GTP bindingIDAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0031406carboxylic acid bindingIEAmolecular_function
GO:0004613phosphoenolpyruvate carboxykinase (GTP) activityISSmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0046327glycerol biosynthetic process from pyruvateIEAbiological_process
GO:0004613phosphoenolpyruvate carboxykinase (GTP) activityIEAmolecular_function


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