Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDK4_HUMAN
Description:pyruvate dehydrogenase kinase, isozyme 4 [Source:HGNC Symbol;Acc:8812]
Location:chr7 q21.3
Node attribute:kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S368YLKALsSESIEPhosphoSitePlus
S369LKALSsESIEKPhosphoSitePlus
S381PVFNKsAFKHYPhosphoSitePlus

Dephosphorylation site
PDK4_HUMAN do not have dephosphorylation site.

Mutation site
PDK4_HUMAN do not have mutation site.

Differential expressed protein
PDK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDK4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDK4_HUMANODPA_HUMANkinase -> substrateRegPhos
FOXO1_HUMANPDK4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PDK4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0072593reactive oxygen species metabolic processIMPbiological_process
GO:0005739mitochondrionTAScellular_component
GO:0010510regulation of acetyl-CoA biosynthetic process fromIMPbiological_process
GO:0046320regulation of fatty acid oxidationISSbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0006090pyruvate metabolic processTASbiological_process
GO:0005759mitochondrial matrixTAScellular_component
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinasISSmolecular_function
GO:0042593glucose homeostasisISSbiological_process
GO:0008286insulin receptor signaling pathwayIMPbiological_process
GO:0042304regulation of fatty acid biosynthetic processIMPbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0010565regulation of cellular ketone metabolic processISSbiological_process
GO:0009267cellular response to starvationIDAbiological_process
GO:0010906regulation of glucose metabolic processIMPbiological_process
GO:0042594response to starvationISSbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0006885regulation of pHISSbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0006006glucose metabolic processIEAbiological_process
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0071398cellular response to fatty acidIMPbiological_process


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