Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BIRC2_HUMAN
Description:baculoviral IAP repeat containing 2 [Source:HGNC Symbol;Acc:590]
Location:chr11 q22.2
Node attribute:ubiquitination(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S140FAHSLsPTLEHPhosphoSitePlus; HPRD; phosphoELM
Y177SRTNPySYAMSPhosphoSitePlus
S147TLEHSsLFSGSHPRD; phosphoELM
S157SYSSLsPNPLNPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
BIRC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000227758F583YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000227758W316RBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000227758S202*COSMICBreast Cancer20668451
ENSP00000227758K490ECOSMICHead and Neck Cancer21984974
ENSP00000227758G319ECOSMICLung Cancer20668451
ENSP00000227758W31RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
BIRC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BIRC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BIRC2_HUMANTRAF2_HUMANubiquitinationNetPath
BIRC2_HUMANRIPK1_HUMANubiquitinationNetPath
BIRC2_HUMANM3K5_HUMANubiquitinationNetPath
BIRC2_HUMANNEMO_HUMANubiquitinationNetPath
ELK1_HUMANBIRC2_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04621NOD-like receptor signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04210Apoptosis
hsa05222Small cell lung cancer
hsa04064NF-kappa B signaling pathway
hsa05145Toxoplasmosis
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0038061NIK/NF-kappaB cascadeTASbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0003713transcription coactivator activityIMPmolecular_function
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0001890placenta developmentIEAbiological_process
GO:0070266necroptosisIEAbiological_process
GO:0039535regulation of RIG-I signaling pathwayTASbiological_process
GO:0045595regulation of cell differentiationTASbiological_process
GO:0070424regulation of nucleotide-binding oligomerization dTASbiological_process
GO:0034121regulation of toll-like receptor signaling pathwayTASbiological_process
GO:0042127regulation of cell proliferationTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:2000116regulation of cysteine-type endopeptidase activityTASbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0045088regulation of innate immune responseTASbiological_process
GO:0051726regulation of cell cycleIDAbiological_process
GO:0009898internal side of plasma membraneIEAcellular_component
GO:0043161proteasomal ubiquitin-dependent protein catabolic IDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0035631CD40 receptor complexIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0050727regulation of inflammatory responseTASbiological_process


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