Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CYC_HUMAN
Description:cytochrome c, somatic [Source:HGNC Symbol;Acc:19986]
Location:chr7 p15.3
Node attribute:PPI(source); PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T29GGKHKtGPNLHCytochrom_CPhosphoSitePlus
Y98ADLIAyLKKATCytochrom_CPhosphoSitePlus
Y49APGYSyTAANKCytochrom_CPhosphoSitePlus
S48QAPGYsYTAANCytochrom_CPhosphoSitePlus
Y47GQAPGySYTAACytochrom_CPhosphoSitePlus
T29GGKHKtGPNLHHPRD
T79KYIPGtKMIFVCytochrom_CPhosphoSitePlus
Y75ENPKKyIPGTKCytochrom_CPhosphoSitePlus

Dephosphorylation site
CYC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000386270I82VCOSMICHead and Neck Cancer21798893
ENSP00000307786*106CCOSMICOvarian Cancer21720365
ENSP00000307786I82VCOSMICHead and Neck Cancer21798893
ENSP00000387279K54MCOSMICLung Cancer
ENSP00000387279*106CCOSMICOvarian Cancer21720365
ENSP00000386270*106CCOSMICOvarian Cancer21720365
ENSP00000387279I82VCOSMICHead and Neck Cancer21798893
ENSP00000307786K54MCOSMICLung Cancer
ENSP00000386270K54MCOSMICLung Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000387279Renal CancerNormal vs. CancertissueDown0.2919610612

Hyperphosphorylation site
CYC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
B2CL1_HUMANCYC_HUMANotherKEGG
BAD_HUMANCYC_HUMANotherKEGG
CYC_HUMANCASP9_HUMANotherKEGG
TPIP1_HUMANCYC_HUMANotherKEGG
BAX_HUMANCYC_HUMANotherKEGG
BID_HUMANCYC_HUMANotherKEGG
BCL2_HUMANCYC_HUMANotherKEGG
SIAH1_HUMANCYC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04210Apoptosis
hsa05145Toxoplasmosis
hsa05200Pathways in cancer
hsa05010Alzheimer's disease
hsa05152Tuberculosis
hsa05168Herpes simplex infection
hsa05416Viral myocarditis
hsa05016Huntington's disease
hsa05134Legionellosis
hsa05012Parkinson's disease
hsa04115p53 signaling pathway
hsa05164Influenza A
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05222Small cell lung cancer
hsa05210Colorectal cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processIDAbiological_process
GO:0000159protein phosphatase type 2A complexTAScellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0008635activation of cysteine-type endopeptidase activityTASbiological_process
GO:0045155electron transporter, transferring electrons from IDAmolecular_function
GO:0004722protein serine/threonine phosphatase activityTASmolecular_function
GO:0020037heme bindingIEAmolecular_function
GO:0022904respiratory electron transport chainTASbiological_process
GO:0070469respiratory chainIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005506iron ion bindingIEAmolecular_function
GO:0006309apoptotic DNA fragmentationIMPbiological_process
GO:0005758mitochondrial intermembrane spaceTAScellular_component
GO:0005829cytosolIMPcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045333cellular respirationTASbiological_process
GO:0022900electron transport chainIEAbiological_process
GO:0009055electron carrier activityIEAmolecular_function
GO:0005743mitochondrial inner membraneTAScellular_component


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