Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP2BA_HUMAN
Description:protein phosphatase 3, catalytic subunit, alpha isozyme [Source:HGNC Symbol;Acc:9314]
Location:chr4 q24
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S512TNGTDsNGSNSPhosphoSitePlus
S518NGSNSsNIQ__PhosphoSitePlus
S515TDSNGsNSSNIPhosphoSitePlus
S411MARVFsVLREEPhosphoSitePlus

Dephosphorylation site
PP2BA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378323G298DCOSMICMelanoma

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378323Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineUp15585135

Hyperphosphorylation site
PP2BA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PP2BA_HUMANBAD_HUMANphosphatase -> substrateHPRD
PP2BA_HUMANNFAC2_HUMANphosphatase -> substrateNetPath
PP2BA_HUMANRCAN1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04210Apoptosis
hsa04728Dopaminergic synapse
hsa05166HTLV-I infection
hsa04010MAPK signaling pathway
hsa04660T cell receptor signaling pathway
hsa05010Alzheimer's disease
hsa04020Calcium signaling pathway
hsa04380Osteoclast differentiation
hsa04310Wnt signaling pathway
hsa04114Oocyte meiosis
hsa04360Axon guidance
hsa04662B cell receptor signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05152Tuberculosis
hsa04370VEGF signaling pathway
hsa05031Amphetamine addiction
hsa04724Glutamatergic synapse
hsa04720Long-term potentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006470protein dephosphorylationIEAbiological_process
GO:0046676negative regulation of insulin secretionIEAbiological_process
GO:0014883transition between fast and slow fiberIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0033192calmodulin-dependent protein phosphatase activityIDAmolecular_function
GO:0016311dephosphorylationTASbiological_process
GO:0004723calcium-dependent protein serine/threonine phosphaIEAmolecular_function
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0042110T cell activationTASbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0048741skeletal muscle fiber developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0046983protein dimerization activityIPImolecular_function
GO:0035690cellular response to drugIDAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0019899enzyme bindingIDAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016311dephosphorylationIEAbiological_process
GO:0006606protein import into nucleusIEAbiological_process
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0004722protein serine/threonine phosphatase activityNASmolecular_function
GO:0006950response to stressIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0051592response to calcium ionIDAbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0008144drug bindingIDAmolecular_function
GO:0005955calcineurin complexIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005509calcium ion bindingNASmolecular_function
GO:0033173calcineurin-NFAT signaling cascadeIEAbiological_process
GO:0019722calcium-mediated signalingIEAbiological_process