Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARAF_HUMAN
Description:v-raf murine sarcoma 3611 viral oncogene homolog [Source:HGNC Symbol;Acc:646]
Location:chrX p11.23
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T413DVARQtAQGMDPkinase_TyrPhosphoSitePlus
T344KVSQPtAEQAQPkinase_TyrPhosphoSitePlus
T318LKRIGtGSFGTPkinase_TyrPhosphoSitePlus
S532LSPDLsKISSNPkinase_TyrPhosphoSitePlus
S432HRDLKsNNIFLPkinase_TyrPhosphoSitePlus
S214RIRSTsTPNVHPhosphoSitePlus; HPRD; phosphoELM
T181LNELLtPQGPSPhosphoSitePlus; HPRD
S341KVLKVsQPTAEPkinase_TyrPhosphoSitePlus
Y301YRDSGyYWEVPSRCphosphoELM
S600PACLLsAARLVPhosphoSitePlus
Y302RDSGYyWEVPPPhosphoSitePlus
Y301YRDSGyYWEVPSrcRegPhos
T452DFGLAtVKTRWPkinase_TyrPhosphoSitePlus
S212LQRIRsTSTPNPhosphoSitePlus; HPRD; phosphoELM
S265PASVSsGRKSPPhosphoSitePlus
S157QQFYHsVQDLSPhosphoSitePlus
Y24GTVKVyLPNKQRBDPhosphoSitePlus
S320RIGTGsFGTVFPkinase_TyrPhosphoSitePlus
S585SASEPsLHRTQPhosphoSitePlus
Y419AQGMDyLHAKNPkinase_TyrPhosphoSitePlus
S283QRERKsLADDKPhosphoSitePlus
S222NVHMVsTTAPMPhosphoSitePlus; HPRD; phosphoELM
S580PKIERsASEPSPhosphoSitePlus; HPRD
S250GSRGGsDGTPRPhosphoSitePlus
S269SSGRKsPHSKSPhosphoSitePlus; HPRD
S264SPASVsSGRKSPhosphoSitePlus
S299LGYRDsGYYWEPhosphoSitePlus; phosphoELM; RegPhos
S274SPHSKsPAEQRPhosphoSitePlus
T224HMVSTtAPMDSPhosphoSitePlus; HPRD; phosphoELM
T223VHMVStTAPMDPhosphoSitePlus; HPRD; phosphoELM
Y302RDSGYyWEVPPSrcRegPhos
S272RKSPHsKSPAEPhosphoSitePlus; HPRD
S547MRRLLsDCLKFPkinase_TyrPhosphoSitePlus
S535DLSKIsSNCPKPkinase_TyrPhosphoSitePlus
Y42DGMSVyDSLDKRBDPhosphoSitePlus
Y155NRQQFyHSVQDPhosphoSitePlus
T455LATVKtRWSGAPkinase_TyrPhosphoSitePlus
S458VKTRWsGAQPLPkinase_TyrPhosphoSitePlus
T20SRAVGtVKVYLRBDPhosphoSitePlus
T442LHEGLtVKIGDPkinase_TyrPhosphoSitePlus
S582IERSAsEPSLHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S536LSKISsNCPKAPkinase_TyrPhosphoSitePlus
Y301YRDSGyYWEVPPhosphoSitePlus
S573ELLQRsLPKIEPhosphoSitePlus
T589PSLHRtQADELPhosphoSitePlus
T323TGSFGtVFRGRPkinase_TyrPhosphoSitePlus
S186TPQGPsPRTQHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T253GGSDGtPRGSPPhosphoSitePlus; HPRD
Y302RDSGYyWEVPPSRCphosphoELM
Y526MVGRGyLSPDLPkinase_TyrPhosphoSitePlus
S15NGAEPsRAVGTPhosphoSitePlus
S257GTPRGsPSPASPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S229TAPMDsNLIQLPhosphoSitePlus
T215IRSTStPNVHMPhosphoSitePlus; HPRD; phosphoELM
Y296VKNLGyRDSGYPhosphoSitePlus
S259PRGSPsPASVSPhosphoSitePlus; HPRD
S528GRGYLsPDLSKPkinase_TyrPhosphoSitePlus
S262SPSPAsVSSGRPhosphoSitePlus
T213QRIRStSTPNVPhosphoSitePlus; phosphoELM

Dephosphorylation site
ARAF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000366244G331CHPIColorectal Cancer17344846
ENSP00000366244W457*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000366244G331CGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000366244Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.2215169874

Hyperphosphorylation site
ARAF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARAF_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANMP2K1_HUMANkinase -> substrateRegPhos
ARAF_HUMANPCBP2_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANGMEB1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANMBNL1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANCDK16_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANHDAC7_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSETB1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANRUXE_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANARAF_HUMANkinase -> substrateRegPhos
ARAF_HUMANRBM12_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSPAG7_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
RRAS2_HUMANARAF_HUMANotherKEGG
RASH_HUMANARAF_HUMANotherKEGG
RASK_HUMANARAF_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05034Alcoholism
hsa05210Colorectal cancer
hsa05223Non-small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa04730Long-term depression
hsa05213Endometrial cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05214Glioma
hsa05160Hepatitis C
hsa05211Renal cell carcinoma
hsa05215Prostate cancer
hsa04810Regulation of actin cytoskeleton
hsa04720Long-term potentiation
hsa04914Progesterone-mediated oocyte maturation
hsa04012ErbB signaling pathway
hsa05212Pancreatic cancer
hsa04270Vascular smooth muscle contraction
hsa04726Serotonergic synapse
hsa04910Insulin signaling pathway
hsa04650Natural killer cell mediated cytotoxicity

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationNASbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0006464cellular protein modification processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0004674protein serine/threonine kinase activityNASmolecular_function
GO:0005575cellular_componentNDcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0005057receptor signaling protein activityIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function


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