| UniProt/SwissProt ID: | SETB1_HUMAN |
| Description: | SET domain, bifurcated 1 [Source:HGNC Symbol;Acc:10761] |
| Location: | chr1 q21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T338 | IEEYVtAYPNR | PhosphoSitePlus | |
| Y678 | YKPFYyILDIT | PhosphoSitePlus | |
| Y677 | PYKPFyYILDI | PhosphoSitePlus | |
| T507 | GHSSPtSPALS | PhosphoSitePlus | |
| S1163 | QVAVKsTRGFA | SET | PhosphoSitePlus |
| S1108 | SSSTEsEGESG | SET | PhosphoSitePlus |
| T1197 | PVRKNtRQFYD | SET | PhosphoSitePlus |
| S504 | VGSGHsSPTSP | PhosphoSitePlus | |
| S1138 | IQTISsGSEGD | SET | PhosphoSitePlus |
| S1104 | VLTLSsSTESE | SET | PhosphoSitePlus |
| S905 | ESNDDsSDDNF | SET | PhosphoSitePlus |
| T1180 | IAIKStNMASV | HPRD; phosphoELM | |
| S111 | QYRDSsSEDES | PhosphoSitePlus | |
| S1130 | ATAVDsDDIQT | SET | PhosphoSitePlus |
| S501 | PGSVGsGHSSP | PhosphoSitePlus | |
| S1066 | YGYNPsPVKPE | HPRD; phosphoELM; SysPTM | |
| S468 | PAPPLsPQAGD | PhosphoSitePlus | |
| S1179 | GIAIKsTNMAS | phosphoELM | |
| S134 | DDDVLsIDSGD | PhosphoSitePlus | |
| S1140 | TISSGsEGDDF | SET | PhosphoSitePlus |
| T838 | AGKILtDDFAD | SET | PhosphoSitePlus |
| T838 | AGKILtDDFAD | phosphoELM | |
| S350 | MVLLKsGQLIK | PhosphoSitePlus | |
| S474 | PQAGDsDLESQ | PhosphoSitePlus | |
| S872 | KEGYEsDAPCS | SET | PhosphoSitePlus |
| S112 | YRDSSsEDESS | PhosphoSitePlus | |
| S1066 | YGYNPsPVKPE | SET | PhosphoSitePlus; SysPTM |
| S906 | SNDDSsDDNFC | SET | PhosphoSitePlus |
| Y230 | GPGKKyKVKFD | PhosphoSitePlus | |
| T1106 | TLSSStESEGE | SET | PhosphoSitePlus |
| Y673 | RKFQPyKPFYY | PhosphoSitePlus | |
| S1103 | DVLTLsSSTES | SET | PhosphoSitePlus |
| T1197 | PVRKNtRQFYD | HPRD | |
| T1123 | PTAGQtSATAV | SET | PhosphoSitePlus |
| T1101 | PDDVLtLSSST | SET | PhosphoSitePlus |
| T1180 | IAIKStNMASV | SET | PhosphoSitePlus |
| S1190 | VDKGEsAPVRK | SET | PhosphoSitePlus |
| S1137 | DIQTIsSGSEG | SET | PhosphoSitePlus |
| S110 | LQYRDsSSEDE | PhosphoSitePlus | |
| T1119 | TSRKPtAGQTS | SET | PhosphoSitePlus |
| S137 | VLSIDsGDAGS | PhosphoSitePlus | |
| T1135 | SDDIQtISSGS | SET | PhosphoSitePlus |
| S505 | GSGHSsPTSPA | PhosphoSitePlus | |
| S175 | AVNKKsSSQDL | PhosphoSitePlus | |
| S1190 | VDKGEsAPVRK | HPRD; phosphoELM | |
| S862 | LDHIEsVENFK | SET | PhosphoSitePlus |
| S1025 | EAEKAsTSGLG | SET | PhosphoSitePlus |
| Dephosphorylation site |
| SETB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000271640 | Q55R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000357958 | E74Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271640 | R394W | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000271640 | E74Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000357958 | Q55R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000357965 | E74Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271640 | T927P | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000271640 | S504C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000357965 | Q55R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000271640 | Y304C | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| SETB1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SETB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ARAF_HUMAN | SETB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | SETB1_HUMAN | phosphatase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00310 | Lysine degradation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0001833 | inner cell mass cell proliferation | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0034968 | histone lysine methylation | IEA | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0018024 | histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005694 | chromosome | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |