Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRIK5_HUMAN
Description:glutamate receptor, ionotropic, kainate 5 [Source:HGNC Symbol;Acc:4583]
Location:chr19 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S155SRILKsFNYPSANF_receptorPhosphoSitePlus
S480PEPNGsWTGMVPhosphoSitePlus
T482PNGSWtGMVGEPhosphoSitePlus

Dephosphorylation site
GRIK5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262895R41HCOSMICOvarian Cancer21720365
ENSP00000301218N904HBIOMARTBreast Cancer21930507, 21930502
ENSP00000262895Y130*COSMICHead and Neck Cancer21798893
ENSP00000262895R62QCOSMICOvarian Cancer21720365

Differential expressed protein
GRIK5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRIK5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK1_HUMANGRIK5_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005234extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0042802identical protein bindingIEAmolecular_function
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0032983kainate selective glutamate receptor complexIEAcellular_component
GO:0007268synaptic transmissionIEAbiological_process
GO:0008328ionotropic glutamate receptor complexIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0005215transporter activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0008066glutamate receptor activityIEAmolecular_function
GO:0030288outer membrane-bounded periplasmic spaceIEAcellular_component
GO:0015277kainate selective glutamate receptor activityIDAmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0043204perikaryonIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0014069postsynaptic densityIEAcellular_component
GO:0043113receptor clusteringIEAbiological_process
GO:0004970ionotropic glutamate receptor activityIEAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0051649establishment of localization in cellIEAbiological_process
GO:0006810transportIEAbiological_process
GO:0007268synaptic transmissionNASbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0035249synaptic transmission, glutamatergicIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0031630regulation of synaptic vesicle fusion to presynaptIEAbiological_process
GO:0015277kainate selective glutamate receptor activityIEAmolecular_function
GO:0030425dendriteIEAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0006621protein retention in ER lumenIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0042734presynaptic membraneIEAcellular_component
GO:0042391regulation of membrane potentialIEAbiological_process


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