Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WNK1_HUMAN
Description:WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:14540]
Location:chr12 p13.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S378TLKRAsFAKSVHPRD; phosphoELM
S2005ELSEPsHLNGPHPRD
S2294GQLCIsMTSNLPhosphoSitePlus
S2032SGSPHsPHQLSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1116RHEKTsRPKLRPhosphoSitePlus
T60RRRRHtMDKDSPhosphoSitePlus; HPRD
S174PSLVGsKEEPPPhosphoSitePlus; HPRD; phosphoELM
S1300SHSASsLSLQQPhosphoSitePlus; phosphoELM
Y1215QGKDDyGFSGSPhosphoSitePlus
T75ATTTTtEHRFFHPRD
S19GSLFLsPPAPAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1110SVRSRsRHEKTPhosphoSitePlus
T1115SRHEKtSRPKLPhosphoSitePlus
S2037SPHQLsSKSLPPhosphoSitePlus; HPRD; SysPTM
S2270SGRRGsKGHMNPhosphoSitePlus
S1297MNLSHsASSLSPhosphoSitePlus; phosphoELM
T1968TEDKItDTKKEPhosphoSitePlus
S2027DVDDGsGSPHSPhosphoSitePlus; HPRD; phosphoELM
S2012LNGPSsDPEAAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T60RRRRHtMDKDSPKB_groupphosphoELM
S2051LSQSLsNSFNSHPRD
S599EQSSAsQTGIKPhosphoSitePlus
T1970DKITDtKKEGPPhosphoSitePlus
S2053QSLSNsFNSSYHPRD
T1848GPVLAtSSGAGPhosphoSitePlus
S2011HLNGPsSDPEAPhosphoSitePlus; HPRD; phosphoELM
S15SSTPGsLFLSPPhosphoSitePlus; HPRD
S1935ASEAKsDTGQPPhosphoSitePlus
S2121PAAPLsGRRRRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S167KDRPVsQPSLVPhosphoSitePlus; HPRD; phosphoELM
S1959KVGRFsVSKTEPhosphoSitePlus
T12EKQSStPGSLFPhosphoSitePlus; HPRD
S1887SVHFEsSTSESPhosphoSitePlus
S2372LQKSIsNPPGSPhosphoSitePlus; HPRD; SysPTM
S1261RRFIVsPVPESPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T74AATTTtTEHRFPhosphoSitePlus; HPRD
S1108RKSVRsRSRHEPhosphoSitePlus
S170PVSQPsLVGSKPhosphoSitePlus; HPRD
S2286MARKFsAPGQLPhosphoSitePlus
Y2276KGHMNyEGPGMPhosphoSitePlus
S378TLKRAsFAKSVPkinasePhosphoSitePlus
T2247RKGTFtDDLHKPhosphoSitePlus
S1978EGPVAsPPFMDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S2002EKPELsEPSHLPhosphoSitePlus; HPRD; phosphoELM
S2029DDGSGsPHSPHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1253TQVVHsAGRRFPhosphoSitePlus
T373DLGLAtLKRASPkinasePhosphoSitePlus
S1295PGMNLsHSASSPhosphoSitePlus
S11AEKQSsTPGSLPhosphoSitePlus
S2020EAAFLsRDVDDHPRD
S382ASFAKsVIGTPPkinasePhosphoSitePlus
T2128RRRRPtKSKGSPhosphoSitePlus
T2245SSRKGtFTDDLPhosphoSitePlus; HPRD; SysPTM
T72GAAATtTTTEHHPRD
T1810SPEMItVTSAVPhosphoSitePlus; HPRD
S1285DTVAAsTAQSPPhosphoSitePlus
S2038PHQLSsKSLPSHPRD; SysPTM
T1963FSVSKtEDKITPhosphoSitePlus
S1105RHYRKsVRSRSPhosphoSitePlus

Dephosphorylation site
WNK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000313059G1765SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000313059E1199GBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000313059E419QGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000313059S2190CGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000313059E1199GSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000313059F2362LGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000313059Q1799ESjoblom2006, HPI, BIOMART, Greenman2007Breast Cancer15908952, 16959974, 17344846, 18428421, 21930507, 21930502, 16959974, 17344846, 16959974 17344846

Differential expressed protein
WNK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WNK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WNK1_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANSTK39_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANOXSR1_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
PAK4_HUMANWNK1_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANSUFU_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
WNK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006811ion transportIEAbiological_process
GO:0050794regulation of cellular processISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0003084positive regulation of systemic arterial blood preIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0050794regulation of cellular processIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0004860protein kinase inhibitor activityIEAmolecular_function
GO:0006811ion transportISSbiological_process
GO:0048666neuron developmentNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010923negative regulation of phosphatase activityIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0019902phosphatase bindingIDAmolecular_function
GO:0090188negative regulation of pancreatic juice secretionIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function