| UniProt/SwissProt ID: | C2TA_HUMAN |
| Description: | class II, major histocompatibility complex, transactivator [Source:HGNC Symbol;Acc:7067] |
| Location: | chr16 p13.13 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S834 | LPGRLsFLGTR | PRKACA | HPRD |
| S1050 | SLLRLsLYNNC | PKACa | RegPhos |
| S288 | RPGSTsPFAPS | PhosphoSitePlus | |
| S1050 | SLLRLsLYNNC | PKA_group | phosphoELM; RegPhos |
| S427 | AGQGKsYWAGA | NACHT | PhosphoSitePlus |
| S834 | LPGRLsFLGTR | PKA_group | phosphoELM; RegPhos |
| S1050 | SLLRLsLYNNC | PhosphoSitePlus | |
| S834 | LPGRLsFLGTR | PKACa | RegPhos |
| S834 | LPGRLsFLGTR | PhosphoSitePlus | |
| S286 | PDRPGsTSPFA | PhosphoSitePlus | |
| T947 | SSSEDtAGELP | PhosphoSitePlus | |
| S280 | HGLPTsPDRPG | PhosphoSitePlus | |
| S1050 | SLLRLsLYNNC | PRKACA | HPRD |
| S1073 | LPDMVsLRVMD | PhosphoSitePlus | |
| S373 | ARLERsSSKSL | PhosphoSitePlus | |
| T546 | CTLLLtARPRG | NACHT | PhosphoSitePlus |
| S293 | SPFAPsATDLP | PhosphoSitePlus | |
| Y428 | GQGKSyWAGAV | NACHT | PhosphoSitePlus |
| S434 | WAGAVsRAWAC | NACHT | PhosphoSitePlus |
| Dephosphorylation site |
| C2TA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316328 | E89* | COSMIC | Skin Cancer | 21984974 | ENSP00000316328 | A691D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000316328 | A691D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| C2TA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| C2TA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | C2TA_HUMAN | kinase -> substrate | HPRD |
| ATF1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| PRDM1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| IRF1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05340 | Primary immunodeficiency |
| hsa05164 | Influenza A |
| hsa05145 | Toxoplasmosis |
| hsa05152 | Tuberculosis |
| hsa04612 | Antigen processing and presentation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0033613 | activating transcription factor binding | IPI | molecular_function |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0045348 | positive regulation of MHC class II biosynthetic p | IC | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045345 | positive regulation of MHC class I biosynthetic pr | IDA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0032966 | negative regulation of collagen biosynthetic proce | IC | biological_process |
| GO:0046677 | response to antibiotic | IDA | biological_process |
| GO:0032403 | protein complex binding | IDA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IMP | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0034341 | response to interferon-gamma | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |