| UniProt/SwissProt ID: | TRADD_HUMAN |
| Description: | TNFRSF1A-associated via death domain [Source:HGNC Symbol;Acc:12030] |
| Location: | chr16 q22.1 |
| Node attribute: | PPI(source); PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y42 | QKVAVyRALQA | PhosphoSitePlus | |
| S296 | ENELTsLAEDL | Death | PhosphoSitePlus |
| S215 | VNRPLsLKDQQ | PhosphoSitePlus | |
| Dephosphorylation site |
| TRADD_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000341268 | Q60R | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| TRADD_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TRADD_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TRADD_HUMAN | TRAF2_HUMAN | other | KEGG |
| TNR1A_HUMAN | TRADD_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05203 | Viral carcinogenesis |
| hsa04920 | Adipocytokine signaling pathway |
| hsa04210 | Apoptosis |
| hsa05169 | Epstein-Barr virus infection |
| hsa04064 | NF-kappa B signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05160 | Hepatitis C |
| hsa05152 | Tuberculosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043235 | receptor complex | IDA | cellular_component |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | TAS | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0097191 | extrinsic apoptotic signaling pathway | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IEA | biological_process |
| GO:0070513 | death domain binding | IPI | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0060090 | binding, bridging | IPI | molecular_function |
| GO:0006917 | induction of apoptosis | IEA | biological_process |
| GO:0006919 | activation of cysteine-type endopeptidase activity | TAS | biological_process |
| GO:0051798 | positive regulation of hair follicle development | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0019900 | kinase binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |