Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KGP2_HUMAN
Description:protein kinase, cGMP-dependent, type II [Source:HGNC Symbol;Acc:9416]
Location:chr4 q21.21
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y306CLEVEyYDKGDcNMP_bindingPhosphoSitePlus
S117LVSLHsRRGAKPhosphoSitePlus
T109EVHRKtSGLVSPhosphoSitePlus
T609GQKTWtFCGTPPkinase_AGCPhosphoSitePlus
S448RFSSSsPFQNLPhosphoSitePlus
T131SAEPTtRTYDLPhosphoSitePlus
Y307LEVEYyDKGDYcNMP_bindingPhosphoSitePlus

Dephosphorylation site
KGP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378945P579SCOSMICMelanoma21499247
ENSP00000378945N239YCOSMICHepatocellular Carcinoma21822264
ENSP00000264399W716RGreenman2007Intestines Cancer17344846, 18428421
ENSP00000264399E402KBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000264399D761NBIOMARTBreast Cancer21930507, 21930502
ENSP00000264399W716RHPIColorectal Cancer17344846
ENSP00000378945D761NBIOMARTBreast Cancer21930507, 21930502
ENSP00000264399L136MBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000378945W716RHPIColorectal Cancer17344846
ENSP00000378945G2ECOSMICSkin Cancer21984974
ENSP00000378945W716RGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
KGP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KGP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KGP2_HUMANLASP1_HUMANkinase -> substrateHPRD
KGP2_HUMANPTPS_HUMANkinase -> substrateHPRD
KGP2_HUMANPLCB3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04740Olfactory transduction
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030553cGMP bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0046209nitric oxide metabolic processTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004692cGMP-dependent protein kinase activityIEAmolecular_function


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