| UniProt/SwissProt ID: | KGP2_HUMAN |
| Description: | protein kinase, cGMP-dependent, type II [Source:HGNC Symbol;Acc:9416] |
| Location: | chr4 q21.21 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y306 | CLEVEyYDKGD | cNMP_binding | PhosphoSitePlus |
| S117 | LVSLHsRRGAK | PhosphoSitePlus | |
| T109 | EVHRKtSGLVS | PhosphoSitePlus | |
| T609 | GQKTWtFCGTP | Pkinase_AGC | PhosphoSitePlus |
| S448 | RFSSSsPFQNL | PhosphoSitePlus | |
| T131 | SAEPTtRTYDL | PhosphoSitePlus | |
| Y307 | LEVEYyDKGDY | cNMP_binding | PhosphoSitePlus |
| Dephosphorylation site |
| KGP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378945 | P579S | COSMIC | Melanoma | 21499247 | ENSP00000378945 | N239Y | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000264399 | W716R | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000264399 | E402K | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000264399 | D761N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264399 | W716R | HPI | Colorectal Cancer | 17344846 | ENSP00000378945 | D761N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264399 | L136M | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000378945 | W716R | HPI | Colorectal Cancer | 17344846 | ENSP00000378945 | G2E | COSMIC | Skin Cancer | 21984974 | ENSP00000378945 | W716R | Greenman2007 | Intestines Cancer | 17344846, 18428421 |
| Differential expressed protein |
| KGP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KGP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KGP2_HUMAN | LASP1_HUMAN | kinase -> substrate | HPRD |
| KGP2_HUMAN | PTPS_HUMAN | kinase -> substrate | HPRD |
| KGP2_HUMAN | PLCB3_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04740 | Olfactory transduction |
| hsa04540 | Gap junction |
| hsa04730 | Long-term depression |
| hsa04970 | Salivary secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030553 | cGMP binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0046209 | nitric oxide metabolic process | TAS | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0050999 | regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004692 | cGMP-dependent protein kinase activity | IEA | molecular_function |