Human Phosphorylation Mediated
                                 Signaling Transduction Network

Protein information

Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site

Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary

UniProt/SwissProt ID:	R3HD2_HUMAN
Description:	R3H domain containing 2 [Source:HGNC Symbol;Acc:29167]
Location:	chr12 q13.3
Node attribute:	substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y146	DSSQEyTDSTG		PhosphoSitePlus
T453	SRQGStEAADP		PhosphoSitePlus
T316	SRQSStDSELK		PhosphoSitePlus
S853	RQALKsASTDL		PhosphoSitePlus; HPRD; phosphoELM
T872	RVLEVtDLPEG		PhosphoSitePlus
S143	LSRDSsQEYTD		PhosphoSitePlus; phosphoELM
Y930	DLAALyTIVAV		PhosphoSitePlus
T879	LPEGItRTEAD		PhosphoSitePlus
S315	SSRQSsTDSEL		PhosphoSitePlus
T357	GISILtRGDSI		PhosphoSitePlus
S351	KASSFsGISIL		PhosphoSitePlus
S142	MLSRDsSQEYT		PhosphoSitePlus
T147	SSQEYtDSTGI		PhosphoSitePlus
S314	SSSRQsSTDSE		PhosphoSitePlus
S349	VTKASsFSGIS		PhosphoSitePlus; HPRD
T860	STDLGtADVVL		PhosphoSitePlus
S365	DSIGSsKGGSA		PhosphoSitePlus
S361	LTRGDsIGSSK		PhosphoSitePlus
S452	LSRQGsTEAAD		PhosphoSitePlus
S310	LSRTSsSRQSS		PhosphoSitePlus
S139	PRKMLsRDSSQ		PhosphoSitePlus
S855	ALKSAsTDLGT		PhosphoSitePlus; HPRD
S348	PVTKAsSFSGI		PhosphoSitePlus

Dephosphorylation site

R3HD2_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000317903	K34N	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000317903	P719T	BIOMART	Pancreatic Cancer	21930507, 21930502
ENSP00000351784	K34N	BIOMART	Breast Cancer	21930507, 21930502

Differential expressed protein

R3HD2_HUMAN is not differential expressed protein.

Hyperphosphorylation site

R3HD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
ST17A_HUMAN	R3HD2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PIM2_HUMAN	R3HD2_HUMAN	kinase -> substrate	Robert H Newman (2013)

Function Annotation

KEGG Pathway

R3HD2_HUMAN is not in KEGG pathway.

Gene Ontology

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