Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PIM2_HUMAN
Description:pim-2 oncogene [Source:HGNC Symbol;Acc:8987]
Location:chrX p11.23
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S204GTRVYsPPEWIPkinase_CAMKPhosphoSitePlus; SysPTM
Y32AFEAEyRLGPLPkinase_CAMKPhosphoSitePlus
S204GTRVYsPPEWIHPRD; phosphoELM; SysPTM
T195HDEPYtDFDGTHPRD; phosphoELM
T195HDEPYtDFDGTPkinase_CAMKPhosphoSitePlus

Dephosphorylation site
PIM2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365692P252TBIOMARTBreast Cancer21930507, 21930502
ENSP00000365692S276*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PIM2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PIM2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PIM2_HUMANRBPMS_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANCLASR_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANPUM1_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANBAD_HUMANkinase -> substrateRegPhos
PIM2_HUMANRMP_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANR3HD2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05221Acute myeloid leukemia

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0008637apoptotic mitochondrial changesIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010508positive regulation of autophagyISSbiological_process
GO:0009615response to virusIEPbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0007140male meiosisTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0050821protein stabilizationISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleIDAbiological_process


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