Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MPIP3_HUMAN
Description:cell division cycle 25C [Source:HGNC Symbol;Acc:1727]
Location:chr5 q31.2
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T130QLLCStPNGLDCDC2(CDK1RegPhos
S399LVKDMHPRD
S191QAEEIsDELMEPLK3phosphoELM; RegPhos
T37LLERDtSFTVCPhosphoSitePlus; HPRD
S168MKYLGsPITTVphosphoELM; RegPhos
S198ELMEFsLKDQEPLK1HPRD; phosphoELM; RegPhos
Y165DSEMKyLGSPIM-inducer_phospPhosphoSitePlus
S148AMCSSsANKENHPRD; phosphoELM
T130QLLCStPNGLDM-inducer_phospPhosphoSitePlus
S472LVKDMsP____PhosphoSitePlus
S168MKYLGsPITTVCDK1HPRD; phosphoELM
S14TREEGsSGSGPHPRD
Y416ILKGGyRDFFPRhodanesePhosphoSitePlus
S168MKYLGsPITTVJNK2(MAPK9RegPhos
S64NLSILsGGTPKPhosphoSitePlus; HPRD; phosphoELM
T171LGSPItTVPKLM-inducer_phospPhosphoSitePlus
S122HLMKCsPAQLLCDK1HPRD; phosphoELM
S216LYRSPsMPENLp38aRegPhos
S216LYRSPsMPENLMAPK14HPRD
T67ILSGGtPKRCLCDK1HPRD; phosphoELM
T48PDVPRtPVGKFCDC2(CDK1RegPhos
T67ILSGGtPKRCLPhosphoSitePlus; phosphoELM
S38LERDTsFTVCPPhosphoSitePlus; HPRD; phosphoELM
S214SGLYRsPSMPECDK1HPRD; phosphoELM
T48PDVPRtPVGKFPhosphoSitePlus; HPRD; phosphoELM
S198ELMEFsLKDQEPLK3phosphoELM; RegPhos
T236KFKDNtIPDKVM-inducer_phospPhosphoSitePlus
S122HLMKCsPAQLLCDC2RegPhos
S216LYRSPsMPENLCHK1RegPhos
S122HLMKCsPAQLLM-inducer_phospPhosphoSitePlus
S143LYRSPsMPENLHPRD
S61DSANLsILSGSHPRD
S214SGLYRsPSMPEM-inducer_phospPhosphoSitePlus
T48PDVPRtPVGKFCDK1HPRD; phosphoELM
S207QEAKVsRSGLYM-inducer_phospPhosphoSitePlus
S57KFLGDsANLSIPhosphoSitePlus; HPRD; phosphoELM
T172GSPITtVPKLDM-inducer_phospPhosphoSitePlus
T67ILSGGtPKRCLCDC2RegPhos
T67ILSGGtPKRCLCDC2(CDK1RegPhos
S209AKVSRsGLYRSM-inducer_phospPhosphoSitePlus
S214SGLYRsPSMPECDC2RegPhos
S15REEGSsGSGPSPhosphoSitePlus; HPRD
S263LKKTVsLCDITM-inducer_phospPhosphoSitePlus
S216LYRSPsMPENLBRSK1HPRD; phosphoELM; RegPhos
S216LYRSPsMPENLBRSK2HPRD; RegPhos
S146RDAMCsSSANKM-inducer_phospPhosphoSitePlus
S216LYRSPsMPENLMARK3HPRD; RegPhos
S198ELMEFsLKDQEM-inducer_phospPhosphoSitePlus
Y401RSLNQyPALYYRhodanesePhosphoSitePlus
S168MKYLGsPITTVCDC2(CDK1RegPhos
S17EGSSGsGPSFRHPRD; phosphoELM
S214SGLYRsPSMPECDC2(CDK1RegPhos
S216LYRSPsMPENLphosphoELM
Y212SRSGLyRSPSMM-inducer_phospPhosphoSitePlus
S216LYRSPsMPENLCHEK1HPRD
S216LYRSPsMPENLCHEK2HPRD
S216LYRSPsMPENLCHK2phosphoELM; RegPhos
S95MKYLGsPITTVHPRD
S168MKYLGsPITTVM-inducer_phospPhosphoSitePlus
S122HLMKCsPAQLLCDC2(CDK1RegPhos
T130QLLCStPNGLDCDC2RegPhos
T48PDVPRtPVGKFCDC2RegPhos
S214SGLYRsPSMPEphosphoELM
S168MKYLGsPITTVCDC2RegPhos
S61DSANLsILSGGPhosphoSitePlus; HPRD; phosphoELM
S216LYRSPsMPENLPLK3HPRD; RegPhos
S191QAEEIsDELMEM-inducer_phospPhosphoSitePlus
S216LYRSPsMPENLM-inducer_phospPhosphoSitePlus
S216LYRSPsMPENLPKN1HPRD; RegPhos
S449LLRCRsQSKVQPhosphoSitePlus
S148AMCSSsANKENM-inducer_phospPhosphoSitePlus
S472LVKDMHPRD
T130QLLCStPNGLDCDK1HPRD; phosphoELM

Dephosphorylation site
MPIP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000321656P19SCOSMICSkin Cancer21984974
ENSP00000424795D366YCOSMICLung Cancer20668451
ENSP00000321656*474GCOSMICOvarian Cancer21720365
ENSP00000424795P19SCOSMICSkin Cancer21984974
ENSP00000321656D366YCOSMICLung Cancer20668451
ENSP00000424795*474GCOSMICOvarian Cancer21720365
ENSP00000424795L54VCOSMICLung Cancer20668451
ENSP00000321656D154NCOSMICLung Cancer20668451
ENSP00000321656L54VCOSMICLung Cancer20668451
ENSP00000424795D154NCOSMICLung Cancer20668451

Differential expressed protein
MPIP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MPIP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
CDK1_HUMANMPIP3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMPIP3_HUMANkinase -> substrateRegPhos
MK14_HUMANMPIP3_HUMANkinase -> substrateHPRD
BRSK2_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
PLK3_HUMANMPIP3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MARK3_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
CHK1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
CHK2_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
PLK1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK09_HUMANMPIP3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BRSK1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
MPIP3_HUMANP53_HUMANphosphatase -> substrateHPRD
MPIP3_HUMANCDK1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008283cell proliferationTASbiological_process
GO:0006260DNA replicationTASbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0050699WW domain bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0000087M phase of mitotic cell cycleIEAbiological_process
GO:0007088regulation of mitosisTASbiological_process
GO:0000087M phase of mitotic cell cycleNASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0004725protein tyrosine phosphatase activityNASmolecular_function
GO:0007089traversing start control point of mitotic cell cycTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0051726regulation of cell cycleTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0035335peptidyl-tyrosine dephosphorylationNASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007067mitosisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function