| UniProt/SwissProt ID: | IFIT2_HUMAN |
| Description: | interferon-induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:5409] |
| Location: | chr10 q23.31 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2 | ____MsENNKN | PhosphoSitePlus | |
| S191 | DNWPPsQNAID | PhosphoSitePlus | |
| S8 | ENNKNsLESSL | PhosphoSitePlus | |
| S424 | AKMRLsKNGAD | PhosphoSitePlus; HPRD | |
| Y383 | GNFQLyQMKCE | PhosphoSitePlus | |
| Dephosphorylation site |
| IFIT2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360891 | P130L | COSMIC | Melanoma | 21499247 | ENSP00000360891 | L198V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360891 | L198V | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| IFIT2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IFIT2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IRF1_HUMAN | IFIT2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| IFIT2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0032091 | negative regulation of protein binding | IDA | biological_process |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0008637 | apoptotic mitochondrial changes | TAS | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IDA | biological_process |
| GO:0009615 | response to virus | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0035457 | cellular response to interferon-alpha | IEA | biological_process |