| UniProt/SwissProt ID: | P52K_HUMAN |
| Description: | protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) [Source:HGNC Symbol;Acc:9440] |
| Location: | chr11 q13.5 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S566 | QGNLEsQLTSE | PhosphoSitePlus | |
| S606 | ALKCLsLVPSV | PhosphoSitePlus | |
| S610 | LSLVPsVMGQL | PhosphoSitePlus | |
| S513 | FFAAGsLTAVL | PhosphoSitePlus | |
| T515 | AAGSLtAVLHS | PhosphoSitePlus | |
| Y330 | CRGQAyIVSSG | PhosphoSitePlus | |
| S595 | LKDIFsEQHLK | PhosphoSitePlus | |
| S579 | YKETLsVPTVE | PhosphoSitePlus | |
| T47 | DLEDKtPDQLN | THAP | PhosphoSitePlus |
| Dephosphorylation site |
| P52K_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260045 | Y744H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260045 | T745R | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000260045 | R557C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| P52K_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| P52K_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P52K_HUMAN | IF2A_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| P52K_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006950 | response to stress | TAS | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |