Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:E2AK3_HUMAN
Description:eukaryotic translation initiation factor 2-alpha kinase 3 [Source:HGNC Symbol;Acc:3255]
Location:chr2 p11.2
Node attribute:kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S719PSPQRsRSFSVPhosphoSitePlus
T981AYARHtGQVGTphosphoELM
T561ETQCQtENKYDPhosphoSitePlus
Y485YYLPYyKRERNPhosphoSitePlus
T802RSRERtSSSIVPhosphoSitePlus
S803SRERTsSSIVFPhosphoSitePlus
S447PVLVGsDEFDKPhosphoSitePlus
Y464FSHEEySNGALPhosphoSitePlus
Y480PYDNGyYLPYYPhosphoSitePlus
T861SPPRPtTLSLDHPRD
T557RKESEtQCQTEPhosphoSitePlus
S1094RQRSRsLSSSGPhosphoSitePlus
Y484GYYLPyYKRERPhosphoSitePlus
Y481YDNGYyLPYYKPhosphoSitePlus
T177ETVPFtVESLLPQQ_2PhosphoSitePlus
Y474LSILQyPYDNGPhosphoSitePlus
S856ATLSIsPPRPTPhosphoSitePlus
S854SEATLsISPPRPhosphoSitePlus
T982AYARHtGQVGTPkinasePhosphoSitePlus
S845FKPTSsKSSSEPhosphoSitePlus
S555RQRKEsETQCQPhosphoSitePlus
S804RERTSsSIVFEPhosphoSitePlus
S715EIIAPsPQRSRPhosphoSitePlus; HPRD
T441HSPSRtPVLVGPhosphoSitePlus
T862PPRPTtLSLDLHPRD
Y268HFELRyIPDMEPQQ_2PhosphoSitePlus
T705MDPFAtKEHIEPhosphoSitePlus
S1096RSRSLsSSGTKPhosphoSitePlus
S455FDKCLsNDKFSPhosphoSitePlus

Dephosphorylation site
E2AK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000307235E228KCOSMICHead and Neck Cancer21798893
ENSP00000307235M962VBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
E2AK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
E2AK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
E2AK3_HUMANIF2A_HUMANkinase -> substrateHPRD; RegPhos
PSN1_HUMANE2AK3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05164Influenza A
hsa05162Measles
hsa05169Epstein-Barr virus infection
hsa05168Herpes simplex infection
hsa05160Hepatitis C
hsa04141Protein processing in endoplasmic reticulum
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031018endocrine pancreas developmentIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007595lactationIEAbiological_process
GO:0017148negative regulation of translationTASbiological_process
GO:0034976response to endoplasmic reticulum stressIMPbiological_process
GO:0007029endoplasmic reticulum organizationIEAbiological_process
GO:0032933SREBP signaling pathwayIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0006926virus-infected cell apoptotic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0032055negative regulation of translation in response to IEAbiological_process
GO:0017148negative regulation of translationIEAbiological_process
GO:0001503ossificationIMPbiological_process
GO:0005623cellIEAcellular_component
GO:0002063chondrocyte developmentIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001501skeletal system developmentIEAbiological_process
GO:0031016pancreas developmentIEAbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0001501skeletal system developmentISSbiological_process
GO:0031642negative regulation of myelinationIEAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030073insulin secretionIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006983ER overload responseIDAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0019217regulation of fatty acid metabolic processIEAbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0005783endoplasmic reticulumISScellular_component
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006412translationIEAbiological_process
GO:0004694eukaryotic translation initiation factor 2alpha kiIDAmolecular_function
GO:0032057negative regulation of translational initiation inTASbiological_process
GO:0009967positive regulation of signal transductionIEAbiological_process
GO:0051260protein homooligomerizationIMPbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0019722calcium-mediated signalingIEAbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIEAbiological_process
GO:0030282bone mineralizationIEAbiological_process