Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEP_HUMAN
Description:membrane metallo-endopeptidase [Source:HGNC Symbol;Acc:7154]
Location:chr3 q25.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T407TSETAtWRRCAHPRD
S6MGKSEsQMDITPhosphoSitePlus; SysPTM
Y482KERIGyPDDIVPeptidase_M13_NPhosphoSitePlus
Y387SLSRTyKESRNPeptidase_M13_NPhosphoSitePlus
T11SQMDItDINTPPhosphoSitePlus
S4__MGKsESQMDPhosphoSitePlus
Y502YLELNyKEDEYPhosphoSitePlus
S6MDITCSNK2BHPRD; SysPTM
Y497KLNNEyLELNYPhosphoSitePlus
S4SQMDHPRD
Y399FRKALyGTTSEHPRD
T15ITDINtPKPKKPhosphoSitePlus

Dephosphorylation site
NEP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000420389R103LTCGAOvarian Cancer21720365, 18772890
ENSP00000419653R103LTCGAOvarian Cancer21720365, 18772890
ENSP00000353679R103LTCGAOvarian Cancer21720365, 18772890
ENSP00000353679L324*COSMICCentral Nervous System Neoplasms18772396
ENSP00000417079R103LTCGAOvarian Cancer21720365, 18772890
ENSP00000353679G417ECOSMICSkin Cancer21984974
ENSP00000353679E701VCOSMICHead and Neck Cancer21798893
ENSP00000353679R103LCOSMICOvarian Cancer21720365
ENSP00000418525R103LTCGAOvarian Cancer21720365, 18772890
ENSP00000353679N489SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000353679Breast CancerNormal vs. CancertissueDown0.4420739354

Hyperphosphorylation site
NEP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK2B_HUMANNEP_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04614Renin-angiotensin system
hsa05010Alzheimer's disease
hsa04640Hematopoietic cell lineage
hsa04974Protein digestion and absorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030425dendriteIEAcellular_component
GO:0008021synaptic vesicleIEAcellular_component
GO:0006518peptide metabolic processIEAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0071345cellular response to cytokine stimulusIDAbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0008233peptidase activityIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0050435beta-amyloid metabolic processIEAbiological_process
GO:0046449creatinine metabolic processIMPbiological_process
GO:0030424axonIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0004222metalloendopeptidase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005887integral to plasma membraneNAScellular_component
GO:0042277peptide bindingIEAmolecular_function
GO:0001822kidney developmentIEPbiological_process
GO:0071492cellular response to UV-AIDAbiological_process
GO:0004175endopeptidase activityIDAmolecular_function
GO:0044306neuron projection terminusIEAcellular_component
GO:0045202synapseIEAcellular_component
GO:0045202synapseISScellular_component
GO:0019233sensory perception of painIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005903brush borderIDAcellular_component
GO:0071493cellular response to UV-BIDAbiological_process
GO:0006518peptide metabolic processISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0090399replicative senescenceIEPbiological_process


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