Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:1433F_HUMAN
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [Source:HGNC Symbol;Acc:12853]
Location:chr22 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T220SYKDStLIMQL14-3-3PhosphoSitePlus
T168EQMQPtHPIRL14-3-3PhosphoSitePlus
Y216LNEDSyKDSTLHPRD
Y130KMKGDyYRYLA14-3-3PhosphoSitePlus
S119DFQYEsKVFYL14-3-3PhosphoSitePlus
Y49LLSVAyKNVVG14-3-3PhosphoSitePlus
S25YDDMAsAMKAV14-3-3PhosphoSitePlus
Y123ESKVFyLKMKG14-3-3PhosphoSitePlus
S215TLNEDsYKDSTHPRD
S59GARRSsWRVIS14-3-3PhosphoSitePlus
S219DSYKDsTLIMQHPRD
Y216LNEDSyKDSTL14-3-3PhosphoSitePlus
Y133GDYYRyLAEVA14-3-3PhosphoSitePlus
T168EQMQPtHPIRLHPRD
S46DRNLLsVAYKN14-3-3PhosphoSitePlus
S59GARRSsWRVISPDKCphosphoELM
Y131MKGDYyRYLAE14-3-3PhosphoSitePlus
S38LNEPLsNEDRN14-3-3PhosphoSitePlus

Dephosphorylation site
1433F_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248975E156KCOSMICHead and Neck Cancer21798893
ENSP00000248975R57*COSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000248975Hepatocellular CarcinomaNormal vs. Cancercell lineUp4.918646787
ENSP00000248975Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.418646787
ENSP00000248975Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp3.119137550
ENSP00000248975Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp2.319137550
ENSP00000248975breast ductal carcinomaNormal vs. CancertissueUp220020534901
ENSP00000248975Renal CancerNormal vs. CancertissueUp4.319610612

Hyperphosphorylation site
1433F_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RIOK1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
1433F_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002028regulation of sodium ion transportISSbiological_process
GO:0017080sodium channel regulator activityIEAmolecular_function
GO:0014704intercalated discICcellular_component
GO:0044325ion channel bindingISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042921glucocorticoid receptor signaling pathwayIDAbiological_process
GO:0005159insulin-like growth factor receptor bindingISSmolecular_function
GO:0035259glucocorticoid receptor bindingIPImolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0006886intracellular protein transportISSbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019904protein domain specific bindingISSmolecular_function
GO:0005737cytoplasmISScellular_component
GO:0045664regulation of neuron differentiationISSbiological_process
GO:2000649regulation of sodium ion transmembrane transporterISSbiological_process
GO:0050774negative regulation of dendrite morphogenesisISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0044325ion channel bindingIEAmolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0006886intracellular protein transportIEAbiological_process
GO:0050774negative regulation of dendrite morphogenesisIEAbiological_process
GO:0017080sodium channel regulator activityISSmolecular_function
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0048167regulation of synaptic plasticityISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:2000649regulation of sodium ion transmembrane transporterIEAbiological_process
GO:0006713glucocorticoid catabolic processIDAbiological_process


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