Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZN363_HUMAN
Description:ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:17479]
Location:chr4 q21.1
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T154LEDIHtSRVVAzf-RING_2PhosphoSitePlus
Y181MLKEGyRCPLCzf-RING_2PhosphoSitePlus
Y173LHRTCyEEMLKzf-RING_2PhosphoSitePlus
S257GGRRIsLDphosphoELM; SysPTM
T171HLLHRtCYEEMzf-RING_2PhosphoSitePlus
S155EDIHTsRVVAHzf-RING_2PhosphoSitePlus
S257GGRRIsLDQQ_PhosphoSitePlus; SysPTM

Dephosphorylation site
ZN363_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000321239A190VCOSMICPancreatic Cancer

Differential expressed protein
ZN363_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZN363_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMX_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
STK40_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
P53_HUMANZN363_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04120Ubiquitin mediated proteolysis
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0032436positive regulation of proteasomal ubiquitin-depenIDAbiological_process
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0042787protein ubiquitination involved in ubiquitin-depenIDAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0000151ubiquitin ligase complexIDAcellular_component
GO:0002039p53 bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0016567protein ubiquitinationIDAbiological_process
GO:0031398positive regulation of protein ubiquitinationIDAbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function


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