Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UPAR_HUMAN
Description:plasminogen activator, urokinase receptor [Source:HGNC Symbol;Acc:9053]
Location:chr19 q13.31
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T30CMQCKtNGDCRUPAR_LY6PhosphoSitePlus
Y217NGRQCySCKGNUPAR_LY6PhosphoSitePlus

Dephosphorylation site
UPAR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339328R159CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000339328Gastric CancerMetastasiscell lineDown0.4217022644
ENSP00000339328Gastric CancerMetastasiscell lineDown0.4217022644
ENSP00000339328Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.6415169874

Hyperphosphorylation site
UPAR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
UROK_HUMANUPAR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030162regulation of proteolysisNASbiological_process
GO:0006928cellular component movementNASbiological_process
GO:0042730fibrinolysisTASbiological_process
GO:0004872receptor activityNASmolecular_function
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0016255attachment of GPI anchor to proteinTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0043687post-translational protein modificationTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0019898extrinsic to membraneTAScellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007596blood coagulationNASbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0006501C-terminal protein lipidationTASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0030377U-plasminogen activator receptor activityNASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0031225anchored to membraneIEAcellular_component
GO:0016021integral to membraneNAScellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function


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