Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR1A_HUMAN
Description:tumor necrosis factor receptor superfamily, member 1A [Source:HGNC Symbol;Acc:11916]
Location:chr12 p13.31
Node attribute:PPI(target); cleavage(target); substrate; receptor; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y360DPATLyAVVENDeathPhosphoSitePlus
T417PRREAtLELLGDeathPhosphoSitePlus
Y318EVAPPyQGADPPhosphoSitePlus
S381RRLGLsDHEIDDeathPhosphoSitePlus
S86CRECEsGSFTATNFR_c6PhosphoSitePlus
S274PNPSFsPTPGFMAPK1HPRD
T353PQSLDtDDPATPhosphoSitePlus
S402REAQYsMLATWDeathPhosphoSitePlus
T118EISSCtVDRDTTNFR_c6PhosphoSitePlus
T280PTPGFtPTLGFMAPK1HPRD
T90ESGSFtASENHTNFR_c6PhosphoSitePlus
T406YSMLAtWRRRTDeathPhosphoSitePlus
Y401LREAQySMLATDeathPhosphoSitePlus

Dephosphorylation site
TNR1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000162749Q319*COSMICHead and Neck Cancer21798893
ENSP00000162749F144LCOSMICOvarian Cancer21720365
ENSP00000162749E254KCOSMICMelanoma
ENSP00000162749T79MCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000162749Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineUp2.115169874

Hyperphosphorylation site
TNR1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNFA_HUMANTNR1A_HUMANligand -> receptorHPMR
MK01_HUMANTNR1A_HUMANkinase -> substrateHPRD
CASP7_HUMANTNR1A_HUMANcleavageNetPath
TNFA_HUMANTNR1A_HUMANotherKEGG
TNR1A_HUMANTRAF6_HUMANotherKEGG
TNFB_HUMANTNR1A_HUMANotherKEGG
TNR1A_HUMANTRAF2_HUMANotherKEGG
TNR1A_HUMANCASP3_HUMANotherKEGG
TNR1A_HUMANTAB1_HUMANotherKEGG
TNR1A_HUMANDAXX_HUMANotherKEGG
TNR1A_HUMANTRADD_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa05142Chagas disease (American trypanosomiasis)
hsa04060Cytokine-cytokine receptor interaction
hsa05160Hepatitis C
hsa04010MAPK signaling pathway
hsa04380Osteoclast differentiation
hsa04210Apoptosis
hsa05168Herpes simplex infection
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05152Tuberculosis
hsa04920Adipocytokine signaling pathway
hsa05164Influenza A
hsa05145Toxoplasmosis
hsa05166HTLV-I infection
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071392cellular response to estradiol stimulusIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016101diterpenoid metabolic processIEAbiological_process
GO:0033160positive regulation of protein import into nucleusIEAbiological_process
GO:0006693prostaglandin metabolic processIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0000139Golgi membraneIDAcellular_component
GO:0042742defense response to bacteriumIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayISSbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0006952defense responseIEAbiological_process
GO:0009812flavonoid metabolic processIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030424axonIEAcellular_component
GO:0005031tumor necrosis factor-activated receptor activityIEAmolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0033209tumor necrosis factor-mediated signaling pathwayIEAbiological_process
GO:0032715negative regulation of interleukin-6 productionIEAbiological_process
GO:0002020protease bindingIEAmolecular_function
GO:0006954inflammatory responseIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0050728negative regulation of inflammatory responseIMPbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0042511positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0033013tetrapyrrole metabolic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043279response to alkaloidIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0043120tumor necrosis factor bindingIEAmolecular_function
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process