| UniProt/SwissProt ID: | ZFYV9_HUMAN |
| Description: | zinc finger, FYVE domain containing 9 [Source:HGNC Symbol;Acc:6775] |
| Location: | chr1 p32.3 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T275 | ISSQGtDGCPA | PhosphoSitePlus | |
| T30 | ETVSStLLDTK | PhosphoSitePlus | |
| T302 | ISSPRtDLGSP | HPRD | |
| S121 | IKRNYsWDDQC | PhosphoSitePlus | |
| S28 | EDETVsSTLLD | PhosphoSitePlus | |
| Y520 | CYSNIyEQRGN | PhosphoSitePlus | |
| S272 | DSVISsQGTDG | PhosphoSitePlus | |
| Y120 | LIKRNySWDDQ | PhosphoSitePlus | |
| S271 | VDSVIsSQGTD | PhosphoSitePlus | |
| Y516 | SKSECySNIYE | PhosphoSitePlus | |
| T26 | QNEDEtVSSTL | PhosphoSitePlus | |
| S635 | NVCSPsLGNIS | PhosphoSitePlus | |
| S257 | IGRDPsMSAIT | PhosphoSitePlus | |
| Dephosphorylation site |
| ZFYV9_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000287727 | H1172L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360647 | C1405W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000360647 | Q6* | COSMIC | Melanoma | 21499247 | ENSP00000287727 | C1405W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000360647 | E988K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000287727 | E988K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360647 | W1311* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360647 | D479E | COSMIC | Lung Cancer | ENSP00000287727 | C1405W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000287727 | D479E | COSMIC | Lung Cancer | ENSP00000360647 | S1189G | COSMIC | Lung Cancer | ENSP00000360647 | H1172L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000349737 | E929K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360647 | H1172L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000360647 | C1405W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360647 | S1091N | COSMIC | Skin Cancer | 21984974 | ENSP00000287727 | S1189G | COSMIC | Lung Cancer | ENSP00000287727 | Q6* | COSMIC | Melanoma | 21499247 | ENSP00000287727 | S1091N | COSMIC | Skin Cancer | 21984974 | ENSP00000287727 | H1172L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000287727 | W1311* | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ZFYV9_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZFYV9_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZFYV9_HUMAN | SMAD2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04350 | TGF-beta signaling pathway |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | NAS | cellular_component |
| GO:0007183 | SMAD protein complex assembly | IDA | biological_process |
| GO:0007184 | SMAD protein import into nucleus | IMP | biological_process |
| GO:0008236 | serine-type peptidase activity | NAS | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005769 | early endosome | NAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007179 | transforming growth factor beta receptor signaling | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005545 | 1-phosphatidylinositol binding | IDA | molecular_function |
| GO:0006897 | endocytosis | NAS | biological_process |
| GO:0030512 | negative regulation of transforming growth factor | TAS | biological_process |
| GO:0031901 | early endosome membrane | IDA | cellular_component |