Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERN1_HUMAN
Description:endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:3449]
Location:chr17 q23.3
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S551AGSSPsLEQDDPhosphoSitePlus
Y166YTITMyDTKTRPQQ_2PhosphoSitePlus
S724AVGRHsFSRRSPkinasePhosphoSitePlus
Y161LGRTEyTITMYPQQ_2PhosphoSitePlus
S726GRHSFsRRSGVPkinasePhosphoSitePlus
S544SGSSAsKAGSSPhosphoSitePlus
Y117SDGILyMGKKQPhosphoSitePlus
T283SKLTPtLYVGKPhosphoSitePlus
T973PQPPVtPDAL_PhosphoSitePlus
S548ASKAGsSPSLEPhosphoSitePlus
Y179RWNATyFDYAAPQQ_2PhosphoSitePlus
Y289LYVGKySTSLYPhosphoSitePlus
T132VIDLLtGEKQQPQQ_2PhosphoSitePlus
T49AVSKRtGSIKWPQQ_2PhosphoSitePlus

Dephosphorylation site
ERN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000401445S769FHPINeoplasms by Histologic Type17344846
ENSP00000401445P830LHPIOvarian Cancer17344846
ENSP00000401445R635WHPIGastric Cancer17344846
ENSP00000401445N244SHPIRenal Cancer17344846
ENSP00000401445G50ACOSMICOvarian Cancer21720365
ENSP00000401445L474RHPILung Cancer17344846
ENSP00000401445P336LBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
ERN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ERN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PSN1_HUMANERN1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007050cell cycle arrestIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0030176integral to endoplasmic reticulum membraneIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:1900103positive regulation of endoplasmic reticulum unfolIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0006987activation of signaling protein activity involved IDAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0030968endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006397mRNA processingIEAbiological_process
GO:0007050cell cycle arrestISSbiological_process
GO:0004540ribonuclease activityIEAmolecular_function
GO:0004519endonuclease activityIEAmolecular_function
GO:0006917induction of apoptosisISSbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005637nuclear inner membraneIEAcellular_component
GO:0016891endoribonuclease activity, producing 5'-phosphomonIEAmolecular_function
GO:0006917induction of apoptosisIEAbiological_process
GO:0004521endoribonuclease activityIDAmolecular_function
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0004521endoribonuclease activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process


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