Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NICA_HUMAN
Description:nicastrin [Source:HGNC Symbol;Acc:17091]
Location:chr1 q23.2
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S437RARNIsGVVLANicastrinPhosphoSitePlus
T674ELITLtVGFGITMPhosphoSitePlus
S426PLPPSsLQRFLNicastrinPhosphoSitePlus
S425QPLPPsSLQRFNicastrinPhosphoSitePlus
T672ELELItLTVGFTMPhosphoSitePlus

Dephosphorylation site
NICA_HUMAN do not have dephosphorylation site.

Mutation site
NICA_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000294785Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3119120023

Hyperphosphorylation site
NICA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PSN1_HUMANNICA_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050435beta-amyloid metabolic processIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008233peptidase activityIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0006508proteolysisNASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0043085positive regulation of catalytic activityISSbiological_process
GO:0002262myeloid cell homeostasisIEAbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0042987amyloid precursor protein catabolic processTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0006509membrane protein ectodomain proteolysisISSbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0050673epithelial cell proliferationIEAbiological_process
GO:0005765lysosomal membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004175endopeptidase activityIEAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0016485protein processingIEAbiological_process


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