| UniProt/SwissProt ID: | DCE1_HUMAN |
| Description: | glutamate decarboxylase 1 (brain, 67kDa) [Source:HGNC Symbol;Acc:4092] |
| Location: | chr2 q31.1 |
| Node attribute: | ligand; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S571 | FRMVIsNPAAT | PhosphoSitePlus; HPRD | |
| T91 | ARFRRtETDFS | PhosphoSitePlus; HPRD | |
| T91 | ARFRRtETDFS | PRKCE | HPRD |
| Y265 | IMAARyKYFPE | Pyridoxal_deC | PhosphoSitePlus |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T91 | RDARFRRtETDFSNL | PPP2CB | HPRD |
| T91 | RDARFRRtETDFSNL | PPP2CA | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350928 | Q115H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000350928 | Q115H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| DCE1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DCE1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DCE1_HUMAN | GABR2_HUMAN | ligand -> receptor | HPMR |
| DCE1_HUMAN | GRM4_HUMAN | ligand -> receptor | HPMR |
| DCE1_HUMAN | GABR1_HUMAN | ligand -> receptor | HPMR |
| KPCE_HUMAN | DCE1_HUMAN | kinase -> substrate | HPRD |
| PP2AB_HUMAN | DCE1_HUMAN | phosphatase -> substrate | HPRD |
| PP2AA_HUMAN | DCE1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00650 | Butanoate metabolism |
| hsa01100 | Metabolic pathways |
| hsa04940 | Type I diabetes mellitus |
| hsa00250 | Alanine, aspartate and glutamate metabolism |
| hsa00430 | Taurine and hypotaurine metabolism |
| hsa00410 | beta-Alanine metabolism |
| hsa04727 | GABAergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042136 | neurotransmitter biosynthetic process | IEA | biological_process |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0018352 | protein-pyridoxal-5-phosphate linkage | TAS | biological_process |
| GO:0004351 | glutamate decarboxylase activity | IEA | molecular_function |
| GO:0030170 | pyridoxal phosphate binding | IEA | molecular_function |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0012506 | vesicle membrane | NAS | cellular_component |
| GO:0016595 | glutamate binding | IEA | molecular_function |
| GO:0019752 | carboxylic acid metabolic process | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0006540 | glutamate decarboxylation to succinate | TAS | biological_process |
| GO:0016829 | lyase activity | IEA | molecular_function |
| GO:0047485 | protein N-terminus binding | IEA | molecular_function |
| GO:0009449 | gamma-aminobutyric acid biosynthetic process | IEA | biological_process |
| GO:0006520 | cellular amino acid metabolic process | IEA | biological_process |
| GO:0061202 | clathrin-sculpted gamma-aminobutyric acid transpor | TAS | cellular_component |
| GO:0007269 | neurotransmitter secretion | TAS | biological_process |
| GO:0006538 | glutamate catabolic process | TAS | biological_process |
| GO:0016831 | carboxy-lyase activity | IEA | molecular_function |