| UniProt/SwissProt ID: | PAK4_HUMAN |
| Description: | p21 protein (Cdc42/Rac)-activated kinase 4 [Source:HGNC Symbol;Acc:16059] |
| Location: | chr19 q13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S488 | APELIsRLPYG | Pkinase | PhosphoSitePlus |
| S474 | VPRRKsLVGTP | Pkinase | PhosphoSitePlus; SysPTM |
| S242 | LAIPQsSSSSS | HPRD | |
| S104 | SLRRDsPPPPA | PAK4 | HPRD; SysPTM |
| S167 | SSREGsGGPQE | PhosphoSitePlus; phosphoELM; SysPTM | |
| S142 | RFAGHsEAGGG | PhosphoSitePlus; HPRD | |
| S267 | LGPHAsEPQLA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S167 | SSREGsGGPQE | PAK4 | HPRD; SysPTM |
| T478 | KSLVGtPYWMA | phosphoELM | |
| S291 | PPGPRsPQREP | PhosphoSitePlus; phosphoELM; SysPTM | |
| S181 | DKRPLsGPDVG | PAK4 | HPRD; SysPTM |
| S99 | VTRSNsLRRDS | PhosphoSitePlus; phosphoELM | |
| S474 | VPRRKsLVGTP | HPRD; phosphoELM; SysPTM | |
| S291 | PPGPRsPQREP | PAK4 | HPRD; SysPTM |
| S258 | ARGAPsPGVLG | PAK4 | HPRD; SysPTM |
| T207 | GRPFNtYPRAD | PAK4 | HPRD; SysPTM |
| T187 | GPDVGtPQPAG | PhosphoSitePlus; HPRD | |
| S41 | PRQWQsLIEES | HPRD; SysPTM | |
| S195 | PAGLAsGAKLA | PhosphoSitePlus | |
| Y480 | LVGTPyWMAPE | HPRD; phosphoELM | |
| S99 | VTRSNsLRRDS | PAK4 | HPRD |
| T207 | GRPFNtYPRAD | PhosphoSitePlus; phosphoELM; SysPTM | |
| S41 | PRQWQsLIEES | PBD | PhosphoSitePlus; SysPTM |
| S97 | MSVTRsNSLRR | PhosphoSitePlus | |
| S258 | ARGAPsPGVLG | PhosphoSitePlus; SysPTM | |
| T478 | KSLVGtPYWMA | PAK4 | HPRD |
| S181 | DKRPLsGPDVG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T478 | KSLVGtPYWMA | Pkinase | PhosphoSitePlus |
| S148 | EAGGGsGDRRR | PhosphoSitePlus; phosphoELM; SysPTM | |
| Y208 | RPFNTyPRADT | PhosphoSitePlus; HPRD; phosphoELM | |
| S342 | IATVRsSGKLV | HPRD | |
| T277 | APPACtPAAPA | PhosphoSitePlus; HPRD; SysPTM | |
| S148 | EAGGGsGDRRR | PAK4 | HPRD; SysPTM |
| S104 | SLRRDsPPPPA | PhosphoSitePlus; phosphoELM; SysPTM | |
| Dephosphorylation site |
| PAK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353625 | E90D | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000353625 | Y492* | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000351049 | E90D | Ding2008 | Lung Cancer | 18948947 | ENSP00000353625 | G502V | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000351049 | Y492* | Ding2008 | Lung Cancer | 18948947 | ENSP00000351049 | G502V | Ding2008 | Lung Cancer | 18948947 |
| Differential expressed protein |
| PAK4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PAK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PAK4_HUMAN | LC7L2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | BAD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | DCP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | HMGN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | WNK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | ZAP70_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | P53_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | PAK4_HUMAN | kinase -> substrate | HPRD |
| PAK4_HUMAN | KHDR2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | LARP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04012 | ErbB signaling pathway |
| hsa05211 | Renal cell carcinoma |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04360 | Axon guidance |
| hsa04510 | Focal adhesion |
| hsa04660 | T cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0016049 | cell growth | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0007010 | cytoskeleton organization | TAS | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | NAS | molecular_function |
| GO:0016477 | cell migration | TAS | biological_process |