| UniProt/SwissProt ID: | PAK2_HUMAN |
| Description: | p21 protein (Cdc42/Rac)-activated kinase 2 [Source:HGNC Symbol;Acc:8591] |
| Location: | chr3 q29 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y130 | DVLKFyDSNTV | PBD | PhosphoSitePlus |
| T406 | STMVGtPYWMA | Pkinase | PhosphoSitePlus |
| S2 | NGEL | HPRD; phosphoELM | |
| T25 | STIFStGGKDP | PhosphoSitePlus | |
| S36 | LSANHsLKPLP | PhosphoSitePlus | |
| T112 | QTSNItKLEQK | HPRD | |
| S401 | EQSKRsTMVGT | HPRD | |
| S32 | GKDPLsANHSL | PhosphoSitePlus | |
| S55 | RHKIIsIFSGT | PAK2 | HPRD; RegPhos |
| Y139 | TVKQKyLSFTP | PhosphoSitePlus; RegPhos | |
| S197 | SIYTRsVIDPV | PhosphoSitePlus | |
| S20 | PVRMSsTIFST | PAK2 | HPRD; RegPhos |
| S401 | EQSKRsTMVGT | Pkinase | PhosphoSitePlus |
| T143 | KYLSFtPPEKD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S381 | LGMEGsVKLTD | Pkinase | PhosphoSitePlus |
| S141 | KQKYLsFTPPE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S19 | PPVRMsSTIFS | PhosphoSitePlus | |
| S24 | SSTIFsTGGKD | PhosphoSitePlus | |
| T402 | QSKRStMVGTP | autocatalysis | RegPhos |
| S55 | RHKIIsIFSGT | PhosphoSitePlus | |
| S2 | ____MsDNGEL | PhosphoSitePlus | |
| T402 | QSKRStMVGTP | PAK2 | HPRD; RegPhos |
| T154 | GFPSGtPALNA | PhosphoSitePlus | |
| S522 | KEAMKs | HPRD | |
| S141 | KQKYLsFTPPE | PAK2 | HPRD; RegPhos; SysPTM |
| Y130 | DVLKFyDSNTV | SRC | HPRD; phosphoELM; RegPhos |
| T169 | APAVVtEEEDD | PhosphoSitePlus; HPRD; phosphoELM | |
| T402 | QSKRStMVGTP | Pkinase | PhosphoSitePlus |
| Y130 | DVLKFyDSNTV | Src | RegPhos |
| S2 | MSDNGeL | RegPhos | |
| T228 | KKTKMtDEEIM | PhosphoSitePlus | |
| S192 | PDHTKsIYTRS | PAK2 | HPRD; RegPhos |
| Y453 | PLRALyLIATN | Pkinase | PhosphoSitePlus |
| T60 | SIFSGtEKGSK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T21 | VRMSStIFSTG | PhosphoSitePlus | |
| Y443 | EGEPPyLNENP | Pkinase | PhosphoSitePlus |
| T134 | FYDSNtVKQKY | PhosphoSitePlus | |
| S20 | PVRMSsTIFST | PhosphoSitePlus | |
| S507 | LAKPLsSLTPL | PhosphoSitePlus; HPRD | |
| S152 | KDGFPsGTPAL | PhosphoSitePlus; HPRD | |
| Y194 | HTKSIyTRSVI | PhosphoSitePlus | |
| S58 | IISIFsGTEKG | PhosphoSitePlus; HPRD; phosphoELM | |
| S42 | LKPLPsVPEEK | PhosphoSitePlus | |
| S192 | PDHTKsIYTRS | PhosphoSitePlus | |
| T195 | TKSIYtRSVID | PhosphoSitePlus | |
| S132 | LKFYDsNTVKQ | PhosphoSitePlus | |
| S197 | SIYTRsVIDPV | PAK2 | HPRD; RegPhos |
| S19 | PPVRMsSTIFS | PAK2 | HPRD; RegPhos |
| Dephosphorylation site |
| PAK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000314067 | E337K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314067 | E8K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000314067 | D174G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314067 | V211G | COSMIC | Lung Cancer | 20668451 | ENSP00000314067 | E8K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000314067 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.1 | 20804217 | ENSP00000314067 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S20 | APPVRMSsTIFSTGG | ovarian cancer | 19876919 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PAK2_HUMAN | MYLK_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | PAK2_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | RAF1_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | MKNK1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PAK2_HUMAN | PRL_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | MYL9_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | RS6_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | VIME_HUMAN | kinase -> substrate | RegPhos |
| SRC_HUMAN | PAK2_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PAK2_HUMAN | PAK2_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | MERL_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | SYN1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| hsa04510 | Focal adhesion |
| hsa04010 | MAPK signaling pathway |
| hsa04660 | T cell receptor signaling pathway |
| hsa04012 | ErbB signaling pathway |
| hsa05211 | Renal cell carcinoma |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0015629 | actin cytoskeleton | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016310 | phosphorylation | IDA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0006461 | protein complex assembly | IEA | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0050690 | regulation of defense response to virus by virus | TAS | biological_process |
| GO:2001238 | positive regulation of extrinsic apoptotic signali | IMP | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0030296 | protein tyrosine kinase activator activity | IDA | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0040008 | regulation of growth | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0061098 | positive regulation of protein tyrosine kinase act | IDA | biological_process |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0008154 | actin polymerization or depolymerization | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IMP | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphory | IDA | biological_process |
| GO:2001271 | negative regulation of cysteine-type endopeptidase | IDA | biological_process |