| UniProt/SwissProt ID: | PRL_HUMAN |
| Description: | prolactin [Source:HGNC Symbol;Acc:9445] |
| Location: | chr6 p22.3 |
| Node attribute: | substrate; ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S179 | IYPVWsGLPSL | Hormone_1 | PhosphoSitePlus |
| S207 | CLRRDsHKIDN | Hormone_1 | PhosphoSitePlus |
| S194 | EESRLsAYYNL | Hormone_1 | PhosphoSitePlus |
| S163 | MELIVsQVHPE | phosphoELM; RegPhos | |
| S163 | MELIVsQVHPE | Hormone_1 | PhosphoSitePlus |
| S194 | EESRLsAYYNL | phosphoELM; RegPhos | |
| S207 | CLRRDsHKIDN | PAK2 | phosphoELM; RegPhos |
| Dephosphorylation site |
| PRL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PRL_HUMAN do not have mutation site. |
| Differential expressed protein |
| PRL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PRL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PRL_HUMAN | PRLR_HUMAN | ligand -> receptor | HPMR |
| PAK2_HUMAN | PRL_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | PRL_HUMAN | kinase -> substrate | RegPhos |
| PRL_HUMAN | NK1R_HUMAN | other | KEGG |
| PRL_HUMAN | PRLR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005179 | hormone activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007565 | female pregnancy | NAS | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signal | TAS | biological_process |
| GO:0007595 | lactation | IEA | biological_process |
| GO:0040014 | regulation of multicellular organism growth | IEP | biological_process |
| GO:0046427 | positive regulation of JAK-STAT cascade | IDA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0005148 | prolactin receptor binding | TAS | molecular_function |