| UniProt/SwissProt ID: | AURKC_HUMAN |
| Description: | aurora kinase C [Source:HGNC Symbol;Acc:11391] |
| Location: | chr19 q13.43 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T202 | KTMCGtLDYLP | phosphoELM | |
| T202 | KTMCGtLDYLP | Pkinase | PhosphoSitePlus |
| Y58 | KFGNVyLARLK | Pkinase | PhosphoSitePlus |
| S32 | AQQPSsPAMRR | PhosphoSitePlus | |
| S77 | KVLFKsQIEKE | Pkinase | PhosphoSitePlus |
| T179 | SLRRKtMCGTL | HPRD | |
| T164 | SLRRKtMCGTL | HPRD | |
| T198 | SLRRKtMCGTL | Pkinase | PhosphoSitePlus |
| T198 | SLRRKtMCGTL | HPRD; phosphoELM | |
| Dephosphorylation site |
| AURKC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000302898 | E170Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000302898 | S261A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000302898 | H244Q | HPI | Lung Cancer | 17344846 | ENSP00000302898 | E148Q | HPI | Lung Cancer | 17344846 | ENSP00000302898 | G52E | HPI | Lung Cancer | 17344846 | ENSP00000302898 | *310S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| AURKC_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AURKC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AURKC_HUMAN | SMPX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKC_HUMAN | LZTS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKC_HUMAN | PLAL2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKC_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| AURKC_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071777 | positive regulation of cell cycle cytokinesis | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0051256 | spindle midzone assembly involved in mitosis | TAS | biological_process |
| GO:0051233 | spindle midzone | IDA | cellular_component |
| GO:0016570 | histone modification | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0000793 | condensed chromosome | IDA | cellular_component |
| GO:0007126 | meiosis | IEA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0032133 | chromosome passenger complex | TAS | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000910 | cytokinesis | TAS | biological_process |
| GO:0030496 | midbody | IDA | cellular_component |
| GO:0000775 | chromosome, centromeric region | IEA | cellular_component |
| GO:0005819 | spindle | TAS | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0008608 | attachment of spindle microtubules to kinetochore | TAS | biological_process |