Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AURKC_HUMAN
Description:aurora kinase C [Source:HGNC Symbol;Acc:11391]
Location:chr19 q13.43
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T202KTMCGtLDYLPphosphoELM
T202KTMCGtLDYLPPkinasePhosphoSitePlus
Y58KFGNVyLARLKPkinasePhosphoSitePlus
S32AQQPSsPAMRRPhosphoSitePlus
S77KVLFKsQIEKEPkinasePhosphoSitePlus
T179SLRRKtMCGTLHPRD
T164SLRRKtMCGTLHPRD
T198SLRRKtMCGTLPkinasePhosphoSitePlus
T198SLRRKtMCGTLHPRD; phosphoELM

Dephosphorylation site
AURKC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302898E170QTCGAOvarian Cancer21720365, 18772890
ENSP00000302898S261ATCGAOvarian Cancer21720365, 18772890
ENSP00000302898H244QHPILung Cancer17344846
ENSP00000302898E148QHPILung Cancer17344846
ENSP00000302898G52EHPILung Cancer17344846
ENSP00000302898*310SCOSMICOvarian Cancer21720365

Differential expressed protein
AURKC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AURKC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AURKC_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
AURKC_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
AURKC_HUMANPLAL2_HUMANkinase -> substrateRobert H Newman (2013)
AURKC_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
AURKC_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071777positive regulation of cell cycle cytokinesisTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0051256spindle midzone assembly involved in mitosisTASbiological_process
GO:0051233spindle midzoneIDAcellular_component
GO:0016570histone modificationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004712protein serine/threonine/tyrosine kinase activityTASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000793condensed chromosomeIDAcellular_component
GO:0007126meiosisIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0032133chromosome passenger complexTAScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0000910cytokinesisTASbiological_process
GO:0030496midbodyIDAcellular_component
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0005819spindleTAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0008608attachment of spindle microtubules to kinetochoreTASbiological_process


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