| UniProt/SwissProt ID: | MRF_HUMAN |
| Description: | myelin regulatory factor [Source:HGNC Symbol;Acc:1181] |
| Location: | chr11 q12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T319 | IARVQtPPWHP | PhosphoSitePlus | |
| S329 | PPGAPsPGLLQ | PhosphoSitePlus | |
| S938 | NIRAKsWGLSV | PhosphoSitePlus | |
| S782 | AFSVVsMSTLY | TM | PhosphoSitePlus |
| Y343 | SLSGSyLDPNY | PhosphoSitePlus | |
| Y147 | SGSEAySPQQV | PhosphoSitePlus | |
| S1103 | DTQGTsHRWPI | PhosphoSitePlus | |
| Y198 | PPPPHyPVLQR | PhosphoSitePlus | |
| T768 | RFLQGtIIALV | PhosphoSitePlus | |
| T1102 | QDTQGtSHRWP | PhosphoSitePlus | |
| S1079 | LCSLRsKEEPC | PhosphoSitePlus | |
| Dephosphorylation site |
| MRF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000278836 | N974T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265460 | N939T | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| MRF_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MRF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FGFR2_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MARK2_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PRP4B_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HASP_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK2_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK3_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDKL5_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKC_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDK1L_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK11_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CHK2_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MRF_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045893 | positive regulation of transcription, DNA-dependen | ISS | biological_process |
| GO:0022010 | central nervous system myelination | ISS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0032286 | central nervous system myelin maintenance | ISS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0031643 | positive regulation of myelination | ISS | biological_process |
| GO:0014003 | oligodendrocyte development | ISS | biological_process |
| GO:0005634 | nucleus | ISS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0048709 | oligodendrocyte differentiation | ISS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |