| UniProt/SwissProt ID: | PLCZ1_HUMAN |
| Description: | phospholipase C, zeta 1 [Source:HGNC Symbol;Acc:19218] |
| Location: | chr12 p12.3 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| PLCZ1_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| PLCZ1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000266505 | E538Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000266505 | R584C | COSMIC | Lung Cancer | ENSP00000266505 | G592C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000266505 | D12N | COSMIC | Skin Cancer | 21984974 | ENSP00000266505 | G206R | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| PLCZ1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PLCZ1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PLCZ1_HUMAN | ITPR1_HUMAN | other | KEGG |
| PLCZ1_HUMAN | KPCA_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa04070 | Phosphatidylinositol signaling system |
| hsa04020 | Calcium signaling pathway |
| hsa04114 | Oocyte meiosis |
| hsa00562 | Inositol phosphate metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0008081 | phosphoric diester hydrolase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0004629 | phospholipase C activity | IEA | molecular_function |
| GO:0004435 | phosphatidylinositol phospholipase C activity | IEA | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0006629 | lipid metabolic process | IEA | biological_process |
| GO:0016042 | lipid catabolic process | IEA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0007343 | egg activation | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |