Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCE1_HUMAN
Description:phospholipase C, epsilon 1 [Source:HGNC Symbol;Acc:17175]
Location:chr10 q23.33
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S362GLTAWsYIDQKPhosphoSitePlus
S2000NTMSAsSMFNTPhosphoSitePlus
S490STFGGsTGRMMPhosphoSitePlus; HPRD
T1100ESGEVtDDEMAPhosphoSitePlus
S74LPKILsIAREKPhosphoSitePlus
S67EEPSGsNLPKIPhosphoSitePlus
S1597DYESLsDDNILPhosphoSitePlus
S761NGLKNsEKESTPhosphoSitePlus
Y1401LPLSYyYIESSPI-PLC-XPhosphoSitePlus
T486SGLLStFGGSTPhosphoSitePlus
T2005SSMFNtEERKCPhosphoSitePlus
T1259LYTNLtIDENTPhosphoSitePlus
Y1400QLPLSyYYIESPI-PLC-XPhosphoSitePlus
S1595DYDYEsLSDDNPhosphoSitePlus
S1096LMRGEsGEVTDPhosphoSitePlus
S65LKEEPsGSNLPPhosphoSitePlus
Y1402PLSYYyIESSHPI-PLC-XPhosphoSitePlus
S1720SFNKTsGKSSCPhosphoSitePlus

Dephosphorylation site
PLCE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360431P1141RBIOMARTBreast Cancer21930507, 21930502
ENSP00000360438N604STCGAOvarian Cancer21720365, 18772890
ENSP00000360438G1726EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000260766G2034EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000360438P833RBIOMARTBreast Cancer21930507, 21930502
ENSP00000360431G2034EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000360426N604STCGAOvarian Cancer21720365, 18772890
ENSP00000360426G1726EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000360426P833RBIOMARTBreast Cancer21930507, 21930502
ENSP00000260766P1141RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PLCE1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PLCE1_HUMANKPCA_HUMANotherKEGG
PLCE1_HUMANITPR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007200phospholipase C-activating G-protein coupled recepIDAbiological_process
GO:0008277regulation of G-protein coupled receptor protein sIDAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0007010cytoskeleton organizationNASbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0007205protein kinase C-activating G-protein coupled receNASbiological_process
GO:0017016Ras GTPase bindingTASmolecular_function
GO:0007507heart developmentTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0046578regulation of Ras protein signal transductionIDAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0000187activation of MAPK activityIDAbiological_process
GO:0006651diacylglycerol biosynthetic processTASbiological_process
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayNASbiological_process
GO:0006644phospholipid metabolic processICbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0004629phospholipase C activityIDAmolecular_function
GO:0006940regulation of smooth muscle contractionTASbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016042lipid catabolic processIEAbiological_process
GO:0008283cell proliferationNASbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0001558regulation of cell growthTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0032835glomerulus developmentIMPbiological_process
GO:0005829cytosolIDAcellular_component
GO:0019722calcium-mediated signalingTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0048016inositol phosphate-mediated signalingTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0045859regulation of protein kinase activityIDAbiological_process


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