| UniProt/SwissProt ID: | AURKA_HUMAN |
| Description: | aurora kinase A [Source:HGNC Symbol;Acc:11393] |
| Location: | chr20 q13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S53 | LCPSNsSQRIP | HPRD | |
| T287 | PSSRRtTLCGT | Aurora A | phosphoELM |
| S342 | TYKRIsRVEFT | Aurora A | phosphoELM |
| S278 | ADFGWsVHAPS | Aurora A | phosphoELM |
| T292 | TTLCGtLDYLP | Pkinase | PhosphoSitePlus |
| S41 | PLPVNsGQAQR | PhosphoSitePlus; HPRD | |
| S98 | NNTQKsKQPLP | Aurora A | phosphoELM |
| T288 | SSRRTtLCGTL | Pkinase | PhosphoSitePlus |
| S98 | NNTQKsKQPLP | PhosphoSitePlus | |
| S4 | ENCI | HPRD | |
| T16 | GPVKAtAPVGG | Aurora A | phosphoELM |
| Y212 | YLILEyAPLGT | Pkinase | PhosphoSitePlus |
| Y199 | LRLYGyFHDAT | Pkinase | PhosphoSitePlus |
| S226 | ELQKLsKFDEQ | Pkinase | PhosphoSitePlus |
| S67 | QKLVSsHKPVQ | Aurora A | phosphoELM |
| S41 | PLPVNsGQAQR | Aurora A | phosphoELM |
| S66 | AQKLVsSHKPV | HPRD | |
| Y197 | NILRLyGYFHD | Pkinase | PhosphoSitePlus |
| S369 | LKHNPsQRPML | HPRD; phosphoELM | |
| S266 | NLLLGsAGELK | Aurora A | phosphoELM |
| S104 | KQPLPsAPENN | Aurora A | phosphoELM |
| S89 | VPHPVsRPLNN | PhosphoSitePlus | |
| S278 | ADFGWsVHAPS | Pkinase | PhosphoSitePlus |
| T288 | SSRRTtLCGTL | PKA_group | phosphoELM |
| S284 | VHAPSsRRTTL | Pkinase | PhosphoSitePlus |
| S104 | KQPLPsAPENN | PhosphoSitePlus | |
| Y148 | KFGNVyLAREK | Pkinase | PhosphoSitePlus |
| T16 | GPVKAtAPVGG | PhosphoSitePlus | |
| S51 | RVLCPsNSSQR | PhosphoSitePlus; HPRD | |
| S83 | QLQATsVPHPV | PhosphoSitePlus; HPRD | |
| T288 | SSRRTtLCGTL | Aurora A | phosphoELM |
| T288 | SSRRTtLCGTL | PRKACA | HPRD |
| S83 | QLQATsVPHPV | Aurora A | phosphoELM |
| Y148 | KFGNVyLAREK | phosphoELM | |
| S391 | NSSKPsNCQNK | Aurora A | phosphoELM |
| S266 | NLLLGsAGELK | Pkinase | PhosphoSitePlus |
| S116 | EEELAsKQKNE | PhosphoSitePlus; HPRD | |
| S226 | ELQKLsKFDEQ | Aurora A | phosphoELM |
| S67 | QKLVSsHKPVQ | PhosphoSitePlus | |
| S10 | KENCIsGPVKA | PhosphoSitePlus | |
| S342 | TYKRIsRVEFT | Pkinase | PhosphoSitePlus |
| S10 | KENCIsGPVKA | Aurora A | phosphoELM |
| T287 | PSSRRtTLCGT | Pkinase | PhosphoSitePlus |
| S391 | NSSKPsNCQNK | PhosphoSitePlus | |
| T287 | PSSRRtTLCGT | HPRD | |
| S369 | LKHNPsQRPML | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| AURKA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360407 | S398L | Ding2008 | Lung Cancer | 18948947 | ENSP00000360407 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000216911 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000321591 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000379249 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000379251 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000379245 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000216911 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000379247 | S398L | Ding2008 | Lung Cancer | 18948947 | ENSP00000360407 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000360407 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000379247 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000379250 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000379250 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000379247 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000379247 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000321591 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000379249 | S398L | Ding2008 | Lung Cancer | 18948947 | ENSP00000321591 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000379245 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000379245 | S398L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000379249 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000379249 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000379251 | *404S | COSMIC | Central Nervous System Neoplasms | 10560660 | ENSP00000379245 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000216911 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000379251 | S398L | Ding2008 | Lung Cancer | 18948947 | ENSP00000379250 | F31I | OMIM | Colorectal Cancer | 12881723 10511710 9771714 | ENSP00000216911 | S398L | Ding2008 | Lung Cancer | 18948947 | ENSP00000379251 | S155R | HPI | Colorectal Cancer | 19801554 17344846 19801554 | ENSP00000321591 | S398L | Ding2008 | Lung Cancer | 18948947 | ENSP00000379250 | S398L | Ding2008 | Lung Cancer | 18948947 |
| Differential expressed protein |
| AURKA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AURKA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AURKA_HUMAN | MBD3_HUMAN | kinase -> substrate | HPRD |
| AURKA_HUMAN | MPIP2_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | AURKA_HUMAN | kinase -> substrate | RegPhos |
| AURKA_HUMAN | BRCA1_HUMAN | kinase -> substrate | HPRD |
| KPCA_HUMAN | AURKA_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04114 | Oocyte meiosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005819 | spindle | TAS | cellular_component |
| GO:0031625 | ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0031616 | spindle pole centrosome | IDA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0048015 | phosphatidylinositol-mediated signaling | NAS | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0030030 | cell projection organization | IEA | biological_process |
| GO:0007051 | spindle organization | NAS | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031647 | regulation of protein stability | IMP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045840 | positive regulation of mitosis | TAS | biological_process |
| GO:0005813 | centrosome | TAS | cellular_component |
| GO:0046605 | regulation of centrosome cycle | TAS | biological_process |
| GO:0007049 | cell cycle | NAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000278 | mitotic cell cycle | IEA | biological_process |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005876 | spindle microtubule | IDA | cellular_component |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | TAS | biological_process |
| GO:0030496 | midbody | TAS | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0046777 | protein autophosphorylation | TAS | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |