Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY1_HUMAN
Description:adenylate cyclase 1 (brain) [Source:HGNC Symbol;Acc:232]
Location:chr7 p12.3
Node attribute:PPI(source); effector; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y926TIGSTyMAAVGGuanylate_cyc; GlnEPhosphoSitePlus
Y52ALFRGyTLRLEPhosphoSitePlus
S69ALAVLsLLAGAHPRD
T53LFRGYtLRLEQHPRD
T61LEQAAtLKALAHPRD
T935VGLAPtSGTKAGuanylate_cyc; GlnEPhosphoSitePlus
Y416LRKWQyDVWSNGuanylate_cycPhosphoSitePlus

Dephosphorylation site
ADCY1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000297323T401MTCGAOvarian Cancer21720365, 18772890
ENSP00000297323R1008QTCGAOvarian Cancer21720365, 18772890
ENSP00000297323V418MCOSMICOvarian Cancer21720365
ENSP00000297323K494NCOSMICMelanoma21499247
ENSP00000297323R571HTCGAOvarian Cancer21720365, 18772890
ENSP00000297323R1008QCOSMICOvarian Cancer21720365
ENSP00000297323P720SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000297323T401MCOSMICOvarian Cancer21720365
ENSP00000297323P561LCOSMICHead and Neck Cancer21798897
ENSP00000297323P1106SCOSMICSkin Cancer21984974
ENSP00000297323R571HCOSMICOvarian Cancer21720365

Differential expressed protein
ADCY1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADCY1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS1_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG2_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBB3_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAI3_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG8_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAO_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG11_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG13_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG10_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBB1_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG1_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG12_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG5_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBB5_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAI2_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBG3_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAI1_HUMANADCY1_HUMANGprotein -> effectorgpDB
ADCY1_HUMANKPCA_HUMANotherKEGG
CALL6_HUMANADCY1_HUMANotherKEGG
ACM1_HUMANADCY1_HUMANotherKEGG
GNAS3_HUMANADCY1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse
hsa00230Purine metabolism
hsa04970Salivary secretion
hsa05146Amoebiasis
hsa04062Chemokine signaling pathway
hsa04020Calcium signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04916Melanogenesis
hsa04912GnRH signaling pathway
hsa04114Oocyte meiosis
hsa04972Pancreatic secretion
hsa04971Gastric acid secretion
hsa05166HTLV-I infection
hsa04725Cholinergic synapse
hsa04720Long-term potentiation
hsa05032Morphine addiction
hsa05142Chagas disease (American trypanosomiasis)
hsa04976Bile secretion
hsa04727GABAergic synapse
hsa05414Dilated cardiomyopathy
hsa04914Progesterone-mediated oocyte maturation
hsa04540Gap junction
hsa04723Retrograde endocannabinoid signaling

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007268synaptic transmissionTASbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0004016adenylate cyclase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006833water transportTASbiological_process
GO:0007623circadian rhythmIEAbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0006171cAMP biosynthetic processNASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0010226response to lithium ionIEAbiological_process
GO:0008294calcium- and calmodulin-responsive adenylate cyclaNASmolecular_function
GO:0005516calmodulin bindingNASmolecular_function
GO:0008294calcium- and calmodulin-responsive adenylate cyclaIEAmolecular_function
GO:0006171cAMP biosynthetic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007409axonogenesisIEAbiological_process


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