| UniProt/SwissProt ID: | GNAS3_HUMAN |
| Description: | GNAS complex locus [Source:HGNC Symbol;Acc:4392] |
| Location: | chr20 q13.32 |
| Node attribute: | PPI(target); PPI(source) |
| Phosphorylation site |
| GNAS3_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| GNAS3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360115 | R217C | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000323571 | R217C | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000360115 | R243fs*3 | COSMIC | Lung Cancer | 18948947 | ENSP00000360139 | N49K | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000360139 | E89D | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000360139 | R243fs*3 | COSMIC | Lung Cancer | 18948947 | ENSP00000323571 | E89D | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000360139 | R217C | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000360115 | N49K | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000323571 | R243fs*3 | COSMIC | Lung Cancer | 18948947 | ENSP00000360115 | E110K | COSMIC | Head and Neck Cancer | ENSP00000323571 | E110K | COSMIC | Head and Neck Cancer | ENSP00000360115 | E89D | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000360139 | E110K | COSMIC | Head and Neck Cancer | ENSP00000323571 | N49K | Ding2008, COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| GNAS3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GNAS3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNRHR_HUMAN | GNAS3_HUMAN | other | KEGG |
| GNAS3_HUMAN | ADCY1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04976 | Bile secretion |
| hsa04970 | Salivary secretion |
| hsa04724 | Glutamatergic synapse |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04742 | Taste transduction |
| hsa05414 | Dilated cardiomyopathy |
| hsa04972 | Pancreatic secretion |
| hsa04730 | Long-term depression |
| hsa05031 | Amphetamine addiction |
| hsa04961 | Endocrine and other factor-regulated calcium reabs |
| hsa04971 | Gastric acid secretion |
| hsa04540 | Gap junction |
| hsa04020 | Calcium signaling pathway |
| hsa04726 | Serotonergic synapse |
| hsa05034 | Alcoholism |
| hsa05110 | Vibrio cholerae infection |
| hsa05032 | Morphine addiction |
| hsa05030 | Cocaine addiction |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04962 | Vasopressin-regulated water reabsorption |
| hsa04916 | Melanogenesis |
| hsa05146 | Amoebiasis |
| hsa04728 | Dopaminergic synapse |
| hsa04912 | GnRH signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | molecular_function |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0007565 | female pregnancy | NAS | biological_process |
| GO:0030133 | transport vesicle | IEA | cellular_component |
| GO:0009306 | protein secretion | NAS | biological_process |