Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UBE2A_HUMAN
Description:ubiquitin-conjugating enzyme E2A [Source:HGNC Symbol;Acc:12472]
Location:chrX q24
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S120EPNPNsPANSQCDK2HPRD; phosphoELM; RegPhos
S120EPNPNsPANSQCDK1HPRD; phosphoELM
S45EPNPNsPANSQCDK1HPRD
S120EPNPNsPANSQUQ_conPhosphoSitePlus
S120EPNPNsPANSQCDC2RegPhos
S90EPNPNsPANSQCDK2HPRD
S90EPNPNsPANSQCDK1HPRD
S45EPNPNsPANSQCDK2HPRD
S120EPNPNsPANSQCDC2(CDK1RegPhos

Dephosphorylation site
UBE2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360624*78YCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
UBE2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
UBE2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANUBE2A_HUMANkinase -> substrateHPRD; RegPhos
BMX_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANUBE2A_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0006511ubiquitin-dependent protein catabolic processNASbiological_process
GO:0000785chromatinISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0033503HULC complexIDAcellular_component
GO:0006281DNA repairIGIbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0060135maternal process involved in female pregnancyIEAbiological_process
GO:0001741XY bodyIEAcellular_component
GO:0006301postreplication repairNASbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0070936protein K48-linked ubiquitinationIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016881acid-amino acid ligase activityIEAmolecular_function
GO:0000209protein polyubiquitinationTASbiological_process
GO:0000785chromatinIEAcellular_component
GO:0070979protein K11-linked ubiquitinationIDAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0033522histone H2A ubiquitinationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0009411response to UVIGIbiological_process


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