Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PROS_HUMAN
Description:protein S (alpha) [Source:HGNC Symbol;Acc:9456]
Location:chr3 q11.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y259QLCVNyPGGYTPhosphoSitePlus
S122IPDQCsPLPCNEGFPhosphoSitePlus
T104AARQStNAYPDPhosphoSitePlus
Y266GGYTCyCDGKKPhosphoSitePlus

Dephosphorylation site
PROS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377783E545GBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000377783Ovarian CancerNormal vs. CancertissueUp2.320162585

Hyperphosphorylation site
PROS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PROS_HUMANUFO_HUMANligand -> receptorHPMR
PROS_HUMANTYRO3_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002576platelet degranulationTASbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005796Golgi lumenTAScellular_component
GO:0004866endopeptidase inhibitor activityTASmolecular_function
GO:0043687post-translational protein modificationTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0042730fibrinolysisIEAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0045087innate immune responseTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0017187peptidyl-glutamic acid carboxylationTASbiological_process
GO:0030449regulation of complement activationTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0006508proteolysisTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0010951negative regulation of endopeptidase activityTASbiological_process


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