| UniProt/SwissProt ID: | MKNK2_HUMAN |
| Description: | MAP kinase interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:7111] |
| Location: | chr19 p13.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T379 | ENTLPtPMVLQ | HPRD | |
| S437 | RCLQLsPPSQS | HPRD | |
| S15 | QGFHRsFKGQN | PhosphoSitePlus | |
| S76 | ATDSFsGRFED | PhosphoSitePlus | |
| S440 | QLSPPsQSKLA | HPRD | |
| S220 | HPNQVsPVKIC | HPRD | |
| S27 | FELAFsLDQPD | HPRD | |
| T72 | KRGRAtDSFSG | PhosphoSitePlus | |
| S452 | RRQRAsLSSAP | PhosphoSitePlus; HPRD; SysPTM | |
| S74 | GRATDsFSGRF | PhosphoSitePlus; HPRD; phosphoELM | |
| S454 | QRASLsSAPVV | HPRD | |
| Dephosphorylation site |
| MKNK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000250896 | D228N | COSMIC | Breast Cancer | 20668451 | ENSP00000250896 | K390* | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000250896 | F149L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| MKNK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MKNK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MKNK2_HUMAN | SMAD6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK2_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK2_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK2_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | MKNK2_HUMAN | kinase -> substrate | KEGG |
| MKNK2_HUMAN | IF4E_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos; Robert H Newman (2013) |
| MKNK2_HUMAN | ATF4_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04910 | Insulin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0071243 | cellular response to arsenic-containing substance | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006417 | regulation of translation | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030097 | hemopoiesis | IDA | biological_process |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |