| UniProt/SwissProt ID: | TIF1B_HUMAN |
| Description: | tripartite motif containing 28 [Source:HGNC Symbol;Acc:16384] |
| Location: | chr19 q13.43 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S471 | SGVKRsRSGEG | PhosphoSitePlus; HPRD; phosphoELM | |
| T541 | TAPAGtPGAPP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y369 | SKKLIyFQLHR | PhosphoSitePlus | |
| S258 | RKLLAsLVKRL | HPRD; phosphoELM | |
| Y242 | HKDHQyQFLED | zf-B_box; DUF1664 | PhosphoSitePlus |
| S4 | AAAS | HPRD | |
| S479 | GEGEVsGLMRK | PhosphoSitePlus; HPRD | |
| S17 | AASAAsGSPGP | PhosphoSitePlus; HPRD | |
| S50 | SAAASsPAGGG | PhosphoSitePlus; HPRD; phosphoELM | |
| S697 | VVAKLsPANQR | PhosphoSitePlus; HPRD | |
| S596 | RLASPsGSTSS | PhosphoSitePlus; HPRD; phosphoELM | |
| S612 | APEGTsAPGGG | PhosphoSitePlus; HPRD | |
| T620 | GGGPGtLDDSA | HPRD | |
| S756 | LSPPYsSPQEF | PhosphoSitePlus; HPRD; phosphoELM | |
| Y517 | STTEDyNLIVI | PhosphoSitePlus | |
| S19 | SAASGsPGPGE | PhosphoSitePlus; HPRD; phosphoELM | |
| S601 | SGSTSsGLEVV | PhosphoSitePlus; HPRD; phosphoELM | |
| S460 | DDPYSsAEPHV | PhosphoSitePlus | |
| S26 | GPGEGsAGGEK | PhosphoSitePlus; HPRD | |
| S594 | GPRLAsPSGST | PhosphoSitePlus; HPRD; phosphoELM | |
| S757 | SPPYSsPQEFA | PhosphoSitePlus; HPRD; phosphoELM | |
| S683 | EDGSLsLDGAD | PhosphoSitePlus; HPRD | |
| S784 | KADVQsIIGLQ | PhosphoSitePlus | |
| S823 | PGAGLsSQELS | PhosphoSitePlus; HPRD; phosphoELM | |
| S466 | AEPHVsGVKRS | PhosphoSitePlus; HPRD; phosphoELM | |
| S258 | RKLLAsLVKRL | DUF1664 | PhosphoSitePlus |
| S4 | __MAAsAAAAS | PhosphoSitePlus | |
| S681 | KEEDGsLSLDG | PhosphoSitePlus; HPRD | |
| T514 | FPGSTtEDYNL | PhosphoSitePlus | |
| T599 | SPSGStSSGLE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y133 | DIVENyFMRDS | PhosphoSitePlus | |
| S45 | ASASAsAAASS | PhosphoSitePlus; phosphoELM | |
| T611 | VAPEGtSAPGG | PhosphoSitePlus; HPRD; phosphoELM | |
| S9 | SAAAAsAAAAS | PhosphoSitePlus; HPRD | |
| S600 | PSGSTsSGLEV | PhosphoSitePlus; HPRD; phosphoELM | |
| S689 | LDGADsTGVVA | HPRD | |
| S14 | SAAAAsAASGS | PhosphoSitePlus; HPRD | |
| S437 | LSKQGsGSSQP | PhosphoSitePlus; HPRD; phosphoELM | |
| S624 | GTLDDsATICR | PhosphoSitePlus; HPRD; phosphoELM | |
| Y458 | SGDDPySSAEP | PhosphoSitePlus | |
| Y449 | EVQEGyGFGSG | PhosphoSitePlus | |
| Y755 | KLSPPySSPQE | HPRD; phosphoELM | |
| S138 | YFMRDsGSKAA | HPRD | |
| S459 | GDDPYsSAEPH | PhosphoSitePlus | |
| S752 | LQEKLsPPYSS | PhosphoSitePlus; HPRD; phosphoELM | |
| T626 | LDDSAtICRVC | HPRD; phosphoELM | |
| S501 | DLTADsQPPVF | PhosphoSitePlus; HPRD; phosphoELM | |
| S49 | ASAAAsSPAGG | PhosphoSitePlus; HPRD; phosphoELM | |
| S598 | ASPSGsTSSGL | PhosphoSitePlus; HPRD; phosphoELM | |
| S816 | EPPPMsLPGAG | PhosphoSitePlus | |
| S439 | KQGSGsSQPME | PhosphoSitePlus; HPRD; phosphoELM | |
| S453 | GYGFGsGDDPY | PhosphoSitePlus | |
| T536 | TGQPGtAPAGT | PhosphoSitePlus | |
| S473 | VKRSRsGEGEV | PhosphoSitePlus; HPRD; phosphoELM | |
| T498 | LDLDLtADSQP | PhosphoSitePlus; HPRD | |
| S440 | QGSGSsQPMEV | PhosphoSitePlus; HPRD; phosphoELM | |
| S828 | SSQELsGGPGD | PhosphoSitePlus; HPRD; phosphoELM | |
| S824 | GAGLSsQELSG | PhosphoSitePlus; HPRD; phosphoELM | |
| S489 | KVPRVsLERLD | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| TIF1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TIF1B_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000253024 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Down | 0.14 | 19422301 | ENSP00000253024 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.4 | 20625496 |
| Hyperphosphorylation site |
| TIF1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCZ_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK03_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK07_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK2_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK16_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K7_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| IRAK3_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TIF1B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005719 | nuclear euchromatin | IEA | cellular_component |
| GO:0005720 | nuclear heterochromatin | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | ISS | molecular_function |
| GO:0008270 | zinc ion binding | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0070087 | chromo shadow domain binding | IPI | molecular_function |
| GO:0016567 | protein ubiquitination | IDA | biological_process |
| GO:0003713 | transcription coactivator activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0001837 | epithelial to mesenchymal transition | IEA | biological_process |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0045739 | positive regulation of DNA repair | IDA | biological_process |
| GO:0051259 | protein oligomerization | IDA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005654 | nucleoplasm | IEA | cellular_component |
| GO:0060028 | convergent extension involved in axis elongation | IEA | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IDA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0060669 | embryonic placenta morphogenesis | IEA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000785 | chromatin | IEA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005634 | nucleus | ISS | cellular_component |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0016925 | protein sumoylation | IEA | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0001837 | epithelial to mesenchymal transition | ISS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | ISS | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | ISS | biological_process |