Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNAP3_HUMAN
Description:tumor necrosis factor, alpha-induced protein 3 [Source:HGNC Symbol;Acc:11896]
Location:chr6 q23.3
Node attribute:deubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S578SPSPHsCHRAGPhosphoSitePlus; HPRD
Y673TMFEGyCQKCFzf-A20PhosphoSitePlus
T647GKVSPtASRFQPhosphoSitePlus
S381SVPQLsLMDVKPhosphoSitePlus
S568SKSDPsRLVRSPhosphoSitePlus; phosphoELM
Y306KLLKEyLMVIEHPRD
S573SRLVRsPSPHSPhosphoSitePlus; HPRD
S575LVRSPsPHSCHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S645ASGKVsPTASRPhosphoSitePlus; HPRD; phosphoELM
Y631LCFIEyRENKHPhosphoSitePlus
S459TGGPHsAPPTAPhosphoSitePlus; HPRD; phosphoELM
Y778AKCNGyCNECFzf-A20PhosphoSitePlus
T454NPEEStGGPHSPhosphoSitePlus
T322WDHGTtHLINAHPRD
Y614KAGCVyFGTPEzf-A20PhosphoSitePlus
T321GWDHGtTHLINHPRD
T617CVYFGtPENKGzf-A20PhosphoSitePlus
S466PPTAPsPFLFSPhosphoSitePlus
S649VSPTAsRFQNTPhosphoSitePlus; HPRD; SysPTM
T179MASTDtPMARSOTUPhosphoSitePlus
T625NKGFCtLCFIEzf-A20PhosphoSitePlus
S699EQLRSsQRRDVPhosphoSitePlus

Dephosphorylation site
TNAP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000237289V93fs*3COSMICLymphoma19412164
ENSP00000237289Q737KCOSMICLymphoma19380639
ENSP00000237289A18PCOSMICLymphoma19412164
ENSP00000237289W317*COSMICLymphoma19412163
ENSP00000237289V571ICOSMICLymphoma19412163
ENSP00000237289P574LCOSMICLymphoma21266526
ENSP00000237289S190*COSMICLymphoma19380639
ENSP00000237289G185*COSMICLymphoma22102703
ENSP00000237289E661*COSMICLymphoma19412164
ENSP00000237289L335*COSMICLymphoma19380639
ENSP00000237289T474NCOSMICLymphoma19412163
ENSP00000237289W356*COSMICLymphoma19412164
ENSP00000237289P758RCOSMICLymphoma20544211
ENSP00000237289C103GCOSMICOvarian Cancer21720365
ENSP00000237289N102SCOSMICLymphoma19608751
ENSP00000237289S459*COSMICLymphoma19412164
ENSP00000237289D117VCOSMICLymphoma21266526
ENSP00000237289E3*COSMICLymphoma19412164
ENSP00000237289A586TCOSMICLymphoma21406721
ENSP00000237289W168*COSMICLymphoma19412163
ENSP00000237289L302PCOSMICLymphoma19380639
ENSP00000237289L421VCOSMICOvarian Cancer21720365
ENSP00000237289Y614CCOSMICHead and Neck Cancer21798893
ENSP00000237289R183*COSMICLymphoma19412164
ENSP00000237289P457fs*20COSMICLymphoma19380639
ENSP00000237289P431LCOSMICLung Cancer20668451
ENSP00000237289N776STCGAOvarian Cancer21720365, 18772890
ENSP00000237289K20QCOSMICOvarian Cancer21720365
ENSP00000237289C721fs*71COSMICLymphoma19412164
ENSP00000237289V377MCOSMICLung Cancer
ENSP00000237289A753TCOSMICLymphoma19380639
ENSP00000237289Q593*COSMICLymphoma19907439
ENSP00000237289P235TCOSMICLymphoma20544211
ENSP00000237289E452*COSMICLymphoma19412164
ENSP00000237289N776SCOSMICOvarian Cancer21720365
ENSP00000237289E781DCOSMICLymphoma19380639
ENSP00000237289R271*COSMICLymphoma19412163
ENSP00000237289P656LCOSMICLung Cancer
ENSP00000237289E88*COSMICLymphoma21406721
ENSP00000237289W85*COSMICLymphoma19412164
ENSP00000237289N163fs*53COSMICLymphoma19258598
ENSP00000237289E751KCOSMICLymphoma19380639
ENSP00000237289N772KCOSMICLymphoma19380639
ENSP00000237289E332*COSMICLymphoma19412164
ENSP00000237289K31*COSMICLymphoma21406721
ENSP00000237289C103GTCGAOvarian Cancer21720365, 18772890
ENSP00000237289Q737*COSMICLymphoma22102703
ENSP00000237289R364GCOSMICLymphoma19412163
ENSP00000237289Q490*COSMICLymphoma19412164
ENSP00000237289M476ICOSMICLymphoma21266526
ENSP00000237289W142*COSMICLymphoma19380639
ENSP00000237289C54*COSMICLymphoma19412164
ENSP00000237289E154*COSMICLymphoma19907439

Differential expressed protein
TNAP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TNAP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNAP3_HUMANRIPK1_HUMANubiquitinationNetPath
TNAP3_HUMANRIPK1_HUMANdeubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04621NOD-like receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002237response to molecule of bacterial originIEAbiological_process
GO:0043130ubiquitin bindingIPImolecular_function
GO:0002020protease bindingIPImolecular_function
GO:0070429negative regulation of nucleotide-binding oligomerIEAbiological_process
GO:0034136negative regulation of toll-like receptor 2 signalNASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0032720negative regulation of tumor necrosis factor produIEAbiological_process
GO:0032495response to muramyl dipeptideIEAbiological_process
GO:0019900kinase bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0070536protein K63-linked deubiquitinationIDAbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0061043regulation of vascular wound healingNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016579protein deubiquitinationIEAbiological_process
GO:2000349negative regulation of CD40 signaling pathwayIMPbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0004843ubiquitin-specific protease activityIDAmolecular_function
GO:0072573tolerance induction to lipopolysaccharideIMPbiological_process
GO:0005764lysosomeIEAcellular_component
GO:0043066negative regulation of apoptotic processNASbiological_process
GO:0002677negative regulation of chronic inflammatory responIEAbiological_process
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0032715negative regulation of interleukin-6 productionIEAbiological_process
GO:0050691regulation of defense response to virus by hostNASbiological_process
GO:0004221ubiquitin thiolesterase activityIMPmolecular_function
GO:0070433negative regulation of nucleotide-binding oligomerIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0045779negative regulation of bone resorptionNASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0050728negative regulation of inflammatory responseISSbiological_process
GO:0001922B-1 B cell homeostasisIEAbiological_process
GO:2000347positive regulation of hepatocyte proliferationIEAbiological_process
GO:0002634regulation of germinal center formationIEAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043621protein self-associationIDAmolecular_function
GO:0050869negative regulation of B cell activationIEAbiological_process
GO:0034144negative regulation of toll-like receptor 4 signalNASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0060548negative regulation of cell deathIEAbiological_process
GO:0048662negative regulation of smooth muscle cell proliferIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0032703negative regulation of interleukin-2 productionIMPbiological_process
GO:0090291negative regulation of osteoclast proliferationNASbiological_process
GO:2000352negative regulation of endothelial cell apoptotic IDAbiological_process
GO:0045732positive regulation of protein catabolic processIDAbiological_process
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0034148negative regulation of toll-like receptor 5 signalIEAbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invNASmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process
GO:0034140negative regulation of toll-like receptor 3 signalIDAbiological_process
GO:0070936protein K48-linked ubiquitinationIDAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0032691negative regulation of interleukin-1 beta productiIEAbiological_process
GO:0045736negative regulation of cyclin-dependent protein kiIEAbiological_process
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0031397negative regulation of protein ubiquitinationIDAbiological_process
GO:0051259protein oligomerizationNASbiological_process
GO:0006954inflammatory responseIEAbiological_process