| UniProt/SwissProt ID: | RFFL_HUMAN |
| Description: | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:24821] |
| Location: | chr17 q12 |
| Node attribute: | kinase; ubiquitination(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S240 | PGRRAsLSDLT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S229 | TQSIDsEDSFV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S226 | EDETQsIDSED | PhosphoSitePlus; HPRD | |
| T150 | RTRAStLSPDF | PhosphoSitePlus | |
| T57 | AHFANtARKQT | PhosphoSitePlus | |
| S152 | RASTLsPDFPE | PhosphoSitePlus | |
| S36 | NPGYSsFPSPT | PhosphoSitePlus | |
| S30 | RMQAYsNPGYS | PhosphoSitePlus | |
| S242 | RRASLsDLTDL | PhosphoSitePlus; HPRD; SysPTM | |
| T245 | SLSDLtDLEDI | PhosphoSitePlus; HPRD; phosphoELM | |
| S149 | DRTRAsTLSPD | PhosphoSitePlus | |
| Y34 | YSNPGySSFPS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y29 | ARMQAySNPGY | PhosphoSitePlus | |
| Y211 | QEEPVyLESVA | PhosphoSitePlus | |
| Dephosphorylation site |
| RFFL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| RFFL_HUMAN do not have mutation site. |
| Differential expressed protein |
| RFFL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RFFL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RFFL_HUMAN | RIPK1_HUMAN | kinase -> substrate | NetPath |
| RFFL_HUMAN | RIPK1_HUMAN | ubiquitination | NetPath |
| Function Annotation |
| KEGG Pathway |
| RFFL_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016874 | ligase activity | IEA | molecular_function |
| GO:0006886 | intracellular protein transport | IEA | biological_process |