Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTK6_HUMAN
Description:PTK6 protein tyrosine kinase 6 [Source:HGNC Symbol;Acc:9617]
Location:chr20 q13.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y114KPSADyVLSVRSH2PhosphoSitePlus; SysPTM
S344EDVYLsHDHNIPkinase_TyrPhosphoSitePlus
Y447SSFTSyENPTBrkRegPhos; SysPTM
S159YHRAQsLSHGLPhosphoSitePlus; HPRD; SysPTM
Y447SSFTSyENphosphoELM; SysPTM
Y351DHNIPyKWTAPPkinase_TyrPhosphoSitePlus
Y342IKEDVyLSHDHBRKRegPhos
Y342IKEDVyLSHDHPTK6HPRD
T445RLSSFtSYENPPhosphoSitePlus
S446LSSFTsYENPTPhosphoSitePlus
Y447SSFTSyENPTBRKRegPhos; SysPTM
S117ADYVLsVRDTQSH2PhosphoSitePlus
S446LSSFTsYENHPRD
Y342IKEDVyLSHDHBrkphosphoELM; RegPhos
Y447SSFTSyENPTRegPhos; SysPTM
S111VSEKPsADYVLSH2PhosphoSitePlus
Y342IKEDVyLSHDHPkinase_TyrPhosphoSitePlus
Y127QAVRHyKIWRRSH2PhosphoSitePlus
S279ELLRDsDEKVLPkinase_TyrPhosphoSitePlus
Y351DHNIPyKWTAPphosphoELM; RegPhos
Y447SSFTSyENPT_PhosphoSitePlus; SysPTM
Y342IKEDVyLSHDHautocatalysis RegPhos
Y447SSFTSyENBrkphosphoELM; SysPTM
Y114KPSADyVLSVRHPRD; SysPTM
Y447SSFTSyENPTK6HPRD; SysPTM

Dephosphorylation site
PTK6_HUMAN do not have dephosphorylation site.

Mutation site
PTK6_HUMAN do not have mutation site.

Differential expressed protein
PTK6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y114SH2SEKPSADyVLSVRDTcholangiocellular carcinoma21253578PhosphoSitePlus
Y447RLSSFTSyENPT___cholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PTK6_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANCTBP1_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANSMAD2_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANPAXI_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANPTK6_HUMANkinase -> substrateRegPhos
PTK6_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANTRI26_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANPTK6_HUMANkinase -> substrateRegPhos
PTK6_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANKHDR1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
PTK6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0016477cell migrationIDAbiological_process
GO:0042506tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0061099negative regulation of protein tyrosine kinase actIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0046777protein autophosphorylationIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0045926negative regulation of growthIEAbiological_process
GO:0001726ruffleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0060575intestinal epithelial cell differentiationIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0042503tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0071300cellular response to retinoic acidIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0010976positive regulation of neuron projection developmeIMPbiological_process


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