Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LIPL_HUMAN
Description:lipoprotein lipase [Source:HGNC Symbol;Acc:6677]
Location:chr8 p21.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T75NHSSKtFMVIHLipasePhosphoSitePlus
S21QSLTAsRGGVALipasePhosphoSitePlus
T19WLQSLtASRGGLipasePhosphoSitePlus
Y329RSSKMyLKTRSLipasePhosphoSitePlus
Y414WKSDSyFSWSDPLATPhosphoSitePlus
T438VKAGEtQKKVIPLATPhosphoSitePlus
S196YAEAPsRLSPDHPRD
S17AVWLQsLTASRLipasePhosphoSitePlus
Y343YKVFHyQVKIHPLATPhosphoSitePlus

Dephosphorylation site
LIPL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309757Q133KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000309757Q240*COSMICPancreatic Cancer
ENSP00000309757G256ATCGAOvarian Cancer21720365, 18772890
ENSP00000309757S469PBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000309757G256ACOSMICOvarian Cancer21720365
ENSP00000309757D105HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
LIPL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LIPL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PO2F1_HUMANLIPL_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
LIPL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006629lipid metabolic processTASbiological_process
GO:0070328triglyceride homeostasisIGIbiological_process
GO:0010886positive regulation of cholesterol storageIMPbiological_process
GO:0004806triglyceride lipase activityIEAmolecular_function
GO:0019433triglyceride catabolic processIEAbiological_process
GO:0034371chylomicron remodelingICbiological_process
GO:0034372very-low-density lipoprotein particle remodelingISSbiological_process
GO:0016042lipid catabolic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0010890positive regulation of sequestering of triglyceridIMPbiological_process
GO:0042627chylomicronIEAcellular_component
GO:0017129triglyceride bindingIEAmolecular_function
GO:0006641triglyceride metabolic processISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009986cell surfaceIEAcellular_component
GO:0031225anchored to membraneIEAcellular_component
GO:0034185apolipoprotein bindingIPImolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0004465lipoprotein lipase activityIEAmolecular_function
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0006644phospholipid metabolic processISSbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0034361very-low-density lipoprotein particleIEAcellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0006633fatty acid biosynthetic processISSbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0019432triglyceride biosynthetic processIEAbiological_process
GO:0004620phospholipase activityISSmolecular_function
GO:0010744positive regulation of macrophage derived foam celIEAbiological_process


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