Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PK3C3_HUMAN
Description:phosphatidylinositol 3-kinase, catalytic subunit type 3 [Source:HGNC Symbol;Acc:8974]
Location:chr18 q12.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T625QLFFKtEDGGKHPRD
T305VSYPPtKQLTYPI3KaPhosphoSitePlus
S455LPSVSsPPPASPI3KaPhosphoSitePlus
T163KTPGRtSSTLSPI3K_C2; tRNA_bind_2PhosphoSitePlus
S455LPSVSsPPPASHPRD
Y395EDLLMyLLQLVPI3KaPhosphoSitePlus
S454PLPSVsSPPPAPI3KaPhosphoSitePlus
Y803FRKQCyTAFLHPI3_PI4_kinasePhosphoSitePlus
T488ACKNStLANYLPI3KaPhosphoSitePlus
Y884HKFAQyWRK__PhosphoSitePlus
Y379PTVRRyAVARLPI3KaPhosphoSitePlus
T159SEPTKtPGRTSPI3K_C2; tRNA_bind_2PhosphoSitePlus
S25QLKIGsLEGKRPhosphoSitePlus
S448SQIITsPLPSVPI3KaPhosphoSitePlus
S448SQIITsPLPSVHPRD
S282LRSGPsDHDLKPhosphoSitePlus
S244DGDESsPILTSPhosphoSitePlus; HPRD
Y517KTHEMyLNVMRPI3KaPhosphoSitePlus
S268ENLVEsKHHKLPhosphoSitePlus
S261PDPQMsMENLVPhosphoSitePlus
S164TPGRTsSTLSEPI3K_C2; tRNA_bind_2PhosphoSitePlus
S165PGRTSsTLSEDPI3K_C2; tRNA_bind_2PhosphoSitePlus
T324FRYYLtNQEKAPI3KaPhosphoSitePlus
T668LDLKLtPYKVLPI3_PI4_kinase; DUF4135PhosphoSitePlus
Y322WKFRYyLTNQEPI3KaPhosphoSitePlus
Y321VWKFRyYLTNQPI3KaPhosphoSitePlus
T513QRDPKtHEMYLPI3KaPhosphoSitePlus

Dephosphorylation site
PK3C3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262039D314YDing2008, COSMICLung Cancer18948947
ENSP00000262039D825YBIOMARTBreast Cancer21930507, 21930502
ENSP00000262039S699TDing2008, COSMICLung Cancer18948947
ENSP00000262039L330FDing2008, COSMICLung Cancer18948947
ENSP00000262039G788WDing2008, COSMICLung Cancer18948947
ENSP00000262039D99ACOSMICHepatocellular Carcinoma21822264
ENSP00000262039M187KDing2008, COSMICLung Cancer18948947
ENSP00000262039L593FDing2008, COSMICLung Cancer18948947
ENSP00000262039E711DCOSMICLung Cancer

Differential expressed protein
PK3C3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PK3C3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PK3C3_HUMANCPSF3_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANPK3C3_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANSRSF4_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANMYF6_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PK3C3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procIMPbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0005770late endosomeIDAcellular_component
GO:00163031-phosphatidylinositol-3-kinase activityIMPmolecular_function
GO:0000045autophagic vacuole assemblyIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0016485protein processingIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0005488bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0045022early endosome to late endosome transportIMPbiological_process
GO:0000910cytokinesisIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0043201response to leucineIEAbiological_process
GO:0035004phosphatidylinositol 3-kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0007032endosome organizationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0050708regulation of protein secretionIEAbiological_process
GO:00163031-phosphatidylinositol-3-kinase activityIEAmolecular_function
GO:0046854phosphatidylinositol phosphorylationIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030496midbodyIDAcellular_component


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