| UniProt/SwissProt ID: | NUAK1_HUMAN |
| Description: | NUAK family, SNF1-like kinase, 1 [Source:HGNC Symbol;Acc:14311] |
| Location: | chr12 q23.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S445 | VLLPSsPEAEV | PhosphoSitePlus | |
| Y141 | SKGELyDYISE | Pkinase; YukC | PhosphoSitePlus |
| S371 | RSLKKsKKEND | RegPhos | |
| S600 | RQRIRsCVSAE | AKT1(PKB | RegPhos |
| S215 | QTFCGsPLYAS | RegPhos | |
| S516 | RVTSHsLSCRR | PhosphoSitePlus | |
| S455 | VPGKLsPKQSA | PhosphoSitePlus | |
| S600 | RQRIRsCVSAE | PKB_group | phosphoELM |
| T211 | DKFLQtFCGSP | Pkinase | PhosphoSitePlus |
| S145 | LYDYIsERRRL | Pkinase; YukC | PhosphoSitePlus |
| S499 | NDVMGsSIPSP | PhosphoSitePlus | |
| S388 | DAVPEsPSKLS | PhosphoSitePlus | |
| Y565 | GLSRSySRPSS | HPRD | |
| T211 | DKFLQtFCGSP | RegPhos | |
| S562 | PAEGLsRSYSR | PhosphoSitePlus | |
| S518 | TSHSLsCRRKG | PhosphoSitePlus | |
| T211 | DKFLQtFCGSP | LKB1 | phosphoELM |
| S380 | NDFAQsGQDAV | RegPhos | |
| S22 | LGAPGsPREAV | PhosphoSitePlus | |
| T356 | GLAKPtTSEVM | PhosphoSitePlus | |
| S564 | EGLSRsYSRPS | PhosphoSitePlus; HPRD | |
| S600 | RQRIRsCVSAE | PhosphoSitePlus; phosphoELM | |
| S600 | RQRIRsCVSAE | AKT_group | RegPhos |
| Y143 | GELYDyISERR | Pkinase; YukC | PhosphoSitePlus |
| T211 | DKFLQtFCGSP | LKB1(STK11 | RegPhos |
| Dephosphorylation site |
| NUAK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261402 | R404Q | COSMIC | Melanoma | 21499247 | ENSP00000261402 | R364Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| NUAK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NUAK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK11_HUMAN | NUAK1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| KPCT_HUMAN | NUAK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | NUAK1_HUMAN | kinase -> substrate | RegPhos |
| NUAK1_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK21_HUMAN | NUAK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NUAK1_HUMAN | CASP6_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | NUAK1_HUMAN | kinase -> substrate | RegPhos |
| NUAK1_HUMAN | CDKA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NUAK1_HUMAN | CSDE1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NUAK1_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NUAK1_HUMAN | GNA12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NUAK1_HUMAN | 2AAB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NUAK1_HUMAN | CHK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NUAK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006974 | response to DNA damage stimulus | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0002039 | p53 binding | IPI | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0042127 | regulation of cell proliferation | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0030155 | regulation of cell adhesion | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:2000772 | regulation of cellular senescence | IDA | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0035507 | regulation of myosin-light-chain-phosphatase activ | IDA | biological_process |