| UniProt/SwissProt ID: | MP2K3_HUMAN |
| Description: | mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:6843] |
| Location: | chr17 p11.2 |
| Node attribute: | PPI(source); substrate; kinase; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y214 | FGISGyLVDSV | Pkinase | PhosphoSitePlus |
| S218 | GYLVDsVAKTM | MAP2K3 | phosphoELM; RegPhos |
| S212 | CDFGIsGYLVD | Pkinase | PhosphoSitePlus |
| T222 | DSVAKtMDAGC | MAP2K3 | phosphoELM; RegPhos |
| T193 | DSVAKtMDAGC | HPRD | |
| S15 | ASMPQsKGKSK | PhosphoSitePlus; HPRD | |
| S218 | GYLVDsVAKTM | Pkinase | PhosphoSitePlus |
| T39 | PAPNPtPPRNL | PhosphoSitePlus | |
| S218 | GYLVDsVAKTM | HPRD; RegPhos | |
| T222 | DSVAKtMDAGC | HPRD; RegPhos | |
| S189 | GYLVDsVAKTM | HPRD | |
| Y230 | AGCKPyMAPER | Pkinase | PhosphoSitePlus |
| S249 | GYNVKsDVWSL | Pkinase | PhosphoSitePlus |
| S6 | QPAS | HPRD | |
| S3 | ___MEsPASSQ | PhosphoSitePlus | |
| S101 | RATVNsQEQKR | Pkinase | PhosphoSitePlus |
| T222 | DSVAKtMDAGC | Pkinase | PhosphoSitePlus |
| S253 | KSDVWsLGITM | Pkinase | PhosphoSitePlus |
| S3 | ASSQ | HPRD | |
| Dephosphorylation site |
| MP2K3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000319139 | D221Y | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000319139 | R86W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000345083 | L215V | HPI | Colorectal Cancer | 11414763 | ENSP00000345083 | R175W | HPI | Colorectal Cancer | 11414763 |
| Differential expressed protein |
| MP2K3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MP2K3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MP2K3_HUMAN | MP2K3_HUMAN | kinase -> substrate | RegPhos |
| M3K7_HUMAN | MP2K3_HUMAN | kinase -> substrate | KEGG |
| ZAGL2_HUMAN | MP2K3_HUMAN | kinase -> substrate | RegPhos |
| M3K6_HUMAN | MP2K3_HUMAN | kinase -> substrate | KEGG |
| MP2K3_HUMAN | MK14_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MP2K3_HUMAN | MK12_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| M3K2_HUMAN | MP2K3_HUMAN | kinase -> substrate | KEGG |
| MP2K3_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K5_HUMAN | MP2K3_HUMAN | kinase -> substrate | KEGG |
| PPM1A_HUMAN | MP2K3_HUMAN | phosphatase -> substrate | KEGG |
| MP2K3_HUMAN | MK14_HUMAN | other | KEGG |
| RAC1_HUMAN | MP2K3_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04912 | GnRH signaling pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa05145 | Toxoplasmosis |
| hsa05169 | Epstein-Barr virus infection |
| hsa04010 | MAPK signaling pathway |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa05164 | Influenza A |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0045860 | positive regulation of protein kinase activity | IDA | biological_process |
| GO:0000187 | activation of MAPK activity | IEA | biological_process |
| GO:0004708 | MAP kinase kinase activity | IEA | molecular_function |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0060048 | cardiac muscle contraction | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0051403 | stress-activated MAPK cascade | TAS | biological_process |
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0000187 | activation of MAPK activity | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0042035 | regulation of cytokine biosynthetic process | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |