| UniProt/SwissProt ID: | MRCKA_HUMAN |
| Description: | CDC42 binding protein kinase alpha (DMPK-like) [Source:HGNC Symbol;Acc:1737] |
| Location: | chr1 q42.13 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1532 | NKRRYsFRVPE | HPRD | |
| S1173 | SQLSAsNNKCS | PhosphoSitePlus | |
| Y1416 | TIRLIyFKNKM | HPRD | |
| S1706 | PRKTKsLSLES | HPRD | |
| T846 | LASKMtEELEA | PhosphoSitePlus; HPRD | |
| S1611 | TVFSGsVSIPS | PhosphoSitePlus | |
| S725 | KELHDsEGQQL | Myosin_tail_1 | PhosphoSitePlus |
| S1639 | LSARSsAQNGS | PhosphoSitePlus | |
| T1725 | LSLEStDRGSW | PhosphoSitePlus | |
| S1703 | TASNSsNLSSP | PhosphoSitePlus | |
| Y1544 | NNKRRySFRVP | PhosphoSitePlus | |
| S1629 | PGRSMsASSGL | PhosphoSitePlus | |
| S1724 | SLSLEsTDRGS | PhosphoSitePlus | |
| S1641 | EFSGGsYSAKR | HPRD | |
| Y474 | VQALQySTVDG | Myosin_tail_1 | PhosphoSitePlus |
| S1616 | SVSIPsITKSR | PhosphoSitePlus | |
| S843 | LQALAsKMTEE | PhosphoSitePlus | |
| S2 | EVRL | HPRD | |
| T862 | LGTRAtDMPWK | PhosphoSitePlus | |
| T1492 | LLGLEtIRLIY | HPRD | |
| S1378 | CVGFQsGFLRY | CNH | PhosphoSitePlus |
| S1654 | EFSGGsYSAKR | PhosphoSitePlus | |
| S1545 | NKRRYsFRVPE | PhosphoSitePlus; phosphoELM | |
| T1411 | LLGLEtIRLIY | HPRD | |
| S1557 | LKREFsGGSYS | HPRD | |
| S1719 | PRKTKsLSLES | PhosphoSitePlus; phosphoELM | |
| S475 | QALQYsTVDGP | Myosin_tail_1 | PhosphoSitePlus |
| S1710 | LSSPPsPASPR | PhosphoSitePlus | |
| S856 | ALRNSsLGTRA | PhosphoSitePlus | |
| S1721 | KTKSLsLESTD | PhosphoSitePlus; phosphoELM | |
| T240 | SVAVGtPDYIS | Pkinase | PhosphoSitePlus |
| Y1497 | TIRLIyFKNKM | HPRD | |
| S1700 | RHSTAsNSSNL | PhosphoSitePlus | |
| S1625 | PRKTKsLSLES | HPRD | |
| S1613 | FSGSVsIPSIT | PhosphoSitePlus | |
| Y1510 | TIRLIyFKNKM | PhosphoSitePlus | |
| T403 | PFVGFtYTSSC | Pkinase_C | PhosphoSitePlus |
| S1656 | SGGSYsAKRQP | PhosphoSitePlus | |
| S222 | LADFGsCLKLM | Pkinase | PhosphoSitePlus |
| S1638 | LKREFsGGSYS | HPRD | |
| T765 | LASKMtEELEA | HPRD | |
| T1185 | LMLADtENEKN | PhosphoSitePlus | |
| Y444 | LATEAyERRIK | Myosin_tail_1 | PhosphoSitePlus |
| S1451 | NKRRYsFRVPE | HPRD | |
| S1651 | LKREFsGGSYS | PhosphoSitePlus | |
| S1708 | KTKSLsLESTD | HPRD | |
| T1505 | LLGLEtIRLIY | PhosphoSitePlus | |
| S234 | DGTVQsSVAVG | Pkinase | PhosphoSitePlus |
| S1171 | TASQLsASNNK | PhosphoSitePlus | |
| S2 | ____MsGEVRL | PhosphoSitePlus | |
| S1632 | SMSASsGLSAR | PhosphoSitePlus | |
| S1627 | KTKSLsLESTD | HPRD | |
| S1560 | EFSGGsYSAKR | HPRD | |
| Dephosphorylation site |
| MRCKA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355731 | R328* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355729 | S344C | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000355729 | E175V | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000355731 | I530M | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000355729 | R328* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000335341 | R328* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355727 | R328* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355726 | R328* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355729 | I744L | COSMIC | Gastric Cancer | 21097718 | ENSP00000355729 | R460K | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000355727 | E50K | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000355729 | I530M | COSMIC | Lung Cancer | 18948947 | ENSP00000355729 | E50K | Greenman2007, COSMIC | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000355729 | L1576F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355728 | R328* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355729 | E299Q | Ding2008, COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| MRCKA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MRCKA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MRCKA_HUMAN | LIMK1_HUMAN | kinase -> substrate | HPRD |
| MRCKA_HUMAN | MLRV_HUMAN | kinase -> substrate | HPRD |
| MRCKA_HUMAN | LIMK2_HUMAN | kinase -> substrate | HPRD |
| MRCKA_HUMAN | PP12C_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| MRCKA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0031252 | cell leading edge | ISS | cellular_component |
| GO:0042641 | actomyosin | IDA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0031032 | actomyosin structure organization | IMP | biological_process |
| GO:0031532 | actin cytoskeleton reorganization | IDA | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0000226 | microtubule cytoskeleton organization | IEA | biological_process |
| GO:0016477 | cell migration | IMP | biological_process |
| GO:0007097 | nuclear migration | IEA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005911 | cell-cell junction | ISS | cellular_component |